Novel guaiane endoperoxides, nardoguaianone A-D, from Nardostachys chinensis roots and their antinociceptive and antimalarial activities

Yoshiaki Takaya, Yoshie Takeuji, Megumi Akasaka, Osamu Nakagawasai, Takeshi Tadano, Kensuke Kisara, Hye Sook Kim, Yusuke Wataya, Masatake Niwa, Yoshiteru Oshima

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36 Citations (Scopus)

Abstract

Four novel guaianoids, nardoguaianone A, B, C and D, were isolated from Nardostachys chinensis roots. The structures were elucidated by spectral means and chemical transformation. Antinociceptive activities of the constituents of N. chinensis, including some of the above novel compounds, were investigated by the formalin test. As a result, it was revealed that nardoguaianone A and D showed activity at the second phase of pain induced by formalin injection. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)7673-7678
Number of pages6
JournalTetrahedron
Volume56
Issue number39
DOIs
Publication statusPublished - Sep 22 2000

Keywords

  • Antimalarial activity
  • Antinociceptive activity
  • Formalin test
  • Guaiane
  • Nardostachys chinensis
  • Sesquiterpenoid

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Takaya, Y., Takeuji, Y., Akasaka, M., Nakagawasai, O., Tadano, T., Kisara, K., Kim, H. S., Wataya, Y., Niwa, M., & Oshima, Y. (2000). Novel guaiane endoperoxides, nardoguaianone A-D, from Nardostachys chinensis roots and their antinociceptive and antimalarial activities. Tetrahedron, 56(39), 7673-7678. https://doi.org/10.1016/S0040-4020(00)00682-7