Novel guaiane endoperoxides, nardoguaianone A-D, from Nardostachys chinensis roots and their antinociceptive and antimalarial activities

Yoshiaki Takaya, Yoshie Takeuji, Megumi Akasaka, Osamu Nakagawasai, Takeshi Tadano, Kensuke Kisara, Hye-Sook Kim, Yusuke Wataya, Masatake Niwa, Yoshiteru Oshima

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Four novel guaianoids, nardoguaianone A, B, C and D, were isolated from Nardostachys chinensis roots. The structures were elucidated by spectral means and chemical transformation. Antinociceptive activities of the constituents of N. chinensis, including some of the above novel compounds, were investigated by the formalin test. As a result, it was revealed that nardoguaianone A and D showed activity at the second phase of pain induced by formalin injection. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)7673-7678
Number of pages6
JournalTetrahedron
Volume56
Issue number39
Publication statusPublished - Sep 22 2000

Fingerprint

Nardostachys
Antimalarials
Pain Measurement
Formaldehyde
Pain
Injections
guaiane

Keywords

  • Antimalarial activity
  • Antinociceptive activity
  • Formalin test
  • Guaiane
  • Nardostachys chinensis
  • Sesquiterpenoid

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Takaya, Y., Takeuji, Y., Akasaka, M., Nakagawasai, O., Tadano, T., Kisara, K., ... Oshima, Y. (2000). Novel guaiane endoperoxides, nardoguaianone A-D, from Nardostachys chinensis roots and their antinociceptive and antimalarial activities. Tetrahedron, 56(39), 7673-7678.

Novel guaiane endoperoxides, nardoguaianone A-D, from Nardostachys chinensis roots and their antinociceptive and antimalarial activities. / Takaya, Yoshiaki; Takeuji, Yoshie; Akasaka, Megumi; Nakagawasai, Osamu; Tadano, Takeshi; Kisara, Kensuke; Kim, Hye-Sook; Wataya, Yusuke; Niwa, Masatake; Oshima, Yoshiteru.

In: Tetrahedron, Vol. 56, No. 39, 22.09.2000, p. 7673-7678.

Research output: Contribution to journalArticle

Takaya, Y, Takeuji, Y, Akasaka, M, Nakagawasai, O, Tadano, T, Kisara, K, Kim, H-S, Wataya, Y, Niwa, M & Oshima, Y 2000, 'Novel guaiane endoperoxides, nardoguaianone A-D, from Nardostachys chinensis roots and their antinociceptive and antimalarial activities', Tetrahedron, vol. 56, no. 39, pp. 7673-7678.
Takaya Y, Takeuji Y, Akasaka M, Nakagawasai O, Tadano T, Kisara K et al. Novel guaiane endoperoxides, nardoguaianone A-D, from Nardostachys chinensis roots and their antinociceptive and antimalarial activities. Tetrahedron. 2000 Sep 22;56(39):7673-7678.
Takaya, Yoshiaki ; Takeuji, Yoshie ; Akasaka, Megumi ; Nakagawasai, Osamu ; Tadano, Takeshi ; Kisara, Kensuke ; Kim, Hye-Sook ; Wataya, Yusuke ; Niwa, Masatake ; Oshima, Yoshiteru. / Novel guaiane endoperoxides, nardoguaianone A-D, from Nardostachys chinensis roots and their antinociceptive and antimalarial activities. In: Tetrahedron. 2000 ; Vol. 56, No. 39. pp. 7673-7678.
@article{1efdaf2c86bc401c8270ce7e1d3a7dd5,
title = "Novel guaiane endoperoxides, nardoguaianone A-D, from Nardostachys chinensis roots and their antinociceptive and antimalarial activities",
abstract = "Four novel guaianoids, nardoguaianone A, B, C and D, were isolated from Nardostachys chinensis roots. The structures were elucidated by spectral means and chemical transformation. Antinociceptive activities of the constituents of N. chinensis, including some of the above novel compounds, were investigated by the formalin test. As a result, it was revealed that nardoguaianone A and D showed activity at the second phase of pain induced by formalin injection. (C) 2000 Elsevier Science Ltd.",
keywords = "Antimalarial activity, Antinociceptive activity, Formalin test, Guaiane, Nardostachys chinensis, Sesquiterpenoid",
author = "Yoshiaki Takaya and Yoshie Takeuji and Megumi Akasaka and Osamu Nakagawasai and Takeshi Tadano and Kensuke Kisara and Hye-Sook Kim and Yusuke Wataya and Masatake Niwa and Yoshiteru Oshima",
year = "2000",
month = "9",
day = "22",
language = "English",
volume = "56",
pages = "7673--7678",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "39",

}

TY - JOUR

T1 - Novel guaiane endoperoxides, nardoguaianone A-D, from Nardostachys chinensis roots and their antinociceptive and antimalarial activities

AU - Takaya, Yoshiaki

AU - Takeuji, Yoshie

AU - Akasaka, Megumi

AU - Nakagawasai, Osamu

AU - Tadano, Takeshi

AU - Kisara, Kensuke

AU - Kim, Hye-Sook

AU - Wataya, Yusuke

AU - Niwa, Masatake

AU - Oshima, Yoshiteru

PY - 2000/9/22

Y1 - 2000/9/22

N2 - Four novel guaianoids, nardoguaianone A, B, C and D, were isolated from Nardostachys chinensis roots. The structures were elucidated by spectral means and chemical transformation. Antinociceptive activities of the constituents of N. chinensis, including some of the above novel compounds, were investigated by the formalin test. As a result, it was revealed that nardoguaianone A and D showed activity at the second phase of pain induced by formalin injection. (C) 2000 Elsevier Science Ltd.

AB - Four novel guaianoids, nardoguaianone A, B, C and D, were isolated from Nardostachys chinensis roots. The structures were elucidated by spectral means and chemical transformation. Antinociceptive activities of the constituents of N. chinensis, including some of the above novel compounds, were investigated by the formalin test. As a result, it was revealed that nardoguaianone A and D showed activity at the second phase of pain induced by formalin injection. (C) 2000 Elsevier Science Ltd.

KW - Antimalarial activity

KW - Antinociceptive activity

KW - Formalin test

KW - Guaiane

KW - Nardostachys chinensis

KW - Sesquiterpenoid

UR - http://www.scopus.com/inward/record.url?scp=0034703382&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034703382&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0034703382

VL - 56

SP - 7673

EP - 7678

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 39

ER -