Novel biological response modifiers: Phthalimides with tumor necrosis factor-α production-regulating activity

Hiroyuki Miyachi, Akihiko Azuma, Asuka Ogasawara, Eiji Uchimura, Naoko Watanabe, Yoshiro Kobayashi, Fuminori Kato, Masanari Kato, Yuichi Hashimoto

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Novel N-substituted phthalimides (2-substituted 1H-isoindole-1,3- diones) were prepared, and their effects on tumor necrosis factor-α (TNF- α) production by human leukemia cell line HL-60 stimulated with 12-O- tetradecanoylphorbol 13-acetate (TPA) or okadaic acid (OA) were examined. A structure-activity relationship study of the N-phenylphthalimides and N- benzylphthalimides revealed that their enhancing effect on TPA-induced TNF- α production by HL-60 cells and their inhibiting effect on OA-induced TNF- α production by HL-60 cells are only partially correlated.

Original languageEnglish
Pages (from-to)2858-2865
Number of pages8
JournalJournal of Medicinal Chemistry
Volume40
Issue number18
DOIs
Publication statusPublished - Aug 29 1997
Externally publishedYes

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Phthalimides
Okadaic Acid
HL-60 Cells
Immunologic Factors
Tetradecanoylphorbol Acetate
Isoindoles
Tumor Necrosis Factor-alpha
Acetates
Structure-Activity Relationship
Leukemia
Cell Line
Cells

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Miyachi, H., Azuma, A., Ogasawara, A., Uchimura, E., Watanabe, N., Kobayashi, Y., ... Hashimoto, Y. (1997). Novel biological response modifiers: Phthalimides with tumor necrosis factor-α production-regulating activity. Journal of Medicinal Chemistry, 40(18), 2858-2865. https://doi.org/10.1021/jm970109q

Novel biological response modifiers : Phthalimides with tumor necrosis factor-α production-regulating activity. / Miyachi, Hiroyuki; Azuma, Akihiko; Ogasawara, Asuka; Uchimura, Eiji; Watanabe, Naoko; Kobayashi, Yoshiro; Kato, Fuminori; Kato, Masanari; Hashimoto, Yuichi.

In: Journal of Medicinal Chemistry, Vol. 40, No. 18, 29.08.1997, p. 2858-2865.

Research output: Contribution to journalArticle

Miyachi, H, Azuma, A, Ogasawara, A, Uchimura, E, Watanabe, N, Kobayashi, Y, Kato, F, Kato, M & Hashimoto, Y 1997, 'Novel biological response modifiers: Phthalimides with tumor necrosis factor-α production-regulating activity', Journal of Medicinal Chemistry, vol. 40, no. 18, pp. 2858-2865. https://doi.org/10.1021/jm970109q
Miyachi, Hiroyuki ; Azuma, Akihiko ; Ogasawara, Asuka ; Uchimura, Eiji ; Watanabe, Naoko ; Kobayashi, Yoshiro ; Kato, Fuminori ; Kato, Masanari ; Hashimoto, Yuichi. / Novel biological response modifiers : Phthalimides with tumor necrosis factor-α production-regulating activity. In: Journal of Medicinal Chemistry. 1997 ; Vol. 40, No. 18. pp. 2858-2865.
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