Novel biological response modifiers: Phthalimides with tumor necrosis factor-α production-regulating activity

Hiroyuki Miyachi, Akihiko Azuma, Asuka Ogasawara, Eiji Uchimura, Naoko Watanabe, Yoshiro Kobayashi, Fuminori Kato, Masanari Kato, Yuichi Hashimoto

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Abstract

Novel N-substituted phthalimides (2-substituted 1H-isoindole-1,3- diones) were prepared, and their effects on tumor necrosis factor-α (TNF- α) production by human leukemia cell line HL-60 stimulated with 12-O- tetradecanoylphorbol 13-acetate (TPA) or okadaic acid (OA) were examined. A structure-activity relationship study of the N-phenylphthalimides and N- benzylphthalimides revealed that their enhancing effect on TPA-induced TNF- α production by HL-60 cells and their inhibiting effect on OA-induced TNF- α production by HL-60 cells are only partially correlated.

Original languageEnglish
Pages (from-to)2858-2865
Number of pages8
JournalJournal of Medicinal Chemistry
Volume40
Issue number18
DOIs
Publication statusPublished - Aug 29 1997
Externally publishedYes

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ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Miyachi, H., Azuma, A., Ogasawara, A., Uchimura, E., Watanabe, N., Kobayashi, Y., Kato, F., Kato, M., & Hashimoto, Y. (1997). Novel biological response modifiers: Phthalimides with tumor necrosis factor-α production-regulating activity. Journal of Medicinal Chemistry, 40(18), 2858-2865. https://doi.org/10.1021/jm970109q