Novel bioactive oxazolomycin isomers produced by streptomyces albus JA3453

Hiroshi Kanzaki, Ken Ichi Wada, Teruhiko Nitoda, Kazuyoshi Kawazu

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Two novel oxazolomycin isomers, oxazolomycins B (2) and C (3), were isolated from the fermentation broth of an oxazolomycin-producing strain, Streptomyces albus JA3453. Both compounds are geometrical isomers of oxazolomycin (1), the configurations of their triene moieties being (4′E, 6′E, 8′E) (2) and (4′Z, 6′E, 8′E) (3) while that of oxazolomycin (1) is (4′Z, 6′Z, 8′E). Compounds 2 and 3 exhibited potent inhibitory activity against crown gall formation with the same MIC (0.8 μg/disk) as oxazolomycin. Compounds 2 and 3 showed no antibacterial activity against Agrobacterium tumefaciens, in contrast to oxazolomycin which has specific anti-A. tumefaciens activity.

Original languageEnglish
Pages (from-to)438-442
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume62
Issue number3
DOIs
Publication statusPublished - Jan 1 1998

Keywords

  • Agrobacterium tumefaciens
  • Crown gall formation
  • Plant transformation
  • Potato tuber disk assay

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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