Abstract
Two novel oxazolomycin isomers, oxazolomycins B (2) and C (3), were isolated from the fermentation broth of an oxazolomycin-producing strain, Streptomyces albus JA3453. Both compounds are geometrical isomers of oxazolomycin (1), the configurations of their triene moieties being (4′E, 6′E, 8′E) (2) and (4′Z, 6′E, 8′E) (3) while that of oxazolomycin (1) is (4′Z, 6′Z, 8′E). Compounds 2 and 3 exhibited potent inhibitory activity against crown gall formation with the same MIC (0.8 μg/disk) as oxazolomycin. Compounds 2 and 3 showed no antibacterial activity against Agrobacterium tumefaciens, in contrast to oxazolomycin which has specific anti-A. tumefaciens activity.
| Original language | English |
|---|---|
| Pages (from-to) | 438-442 |
| Number of pages | 5 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 62 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jan 1 1998 |
Keywords
- Agrobacterium tumefaciens
- Crown gall formation
- Plant transformation
- Potato tuber disk assay
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry
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Kanzaki, H., Wada, K. I., Nitoda, T., & Kawazu, K. (1998). Novel bioactive oxazolomycin isomers produced by streptomyces albus JA3453. Bioscience, Biotechnology and Biochemistry, 62(3), 438-442. https://doi.org/10.1271/bbb.62.438