Abstract
Three guaiane-type sesquiterpenoids, nardoperoxide (1a), isonardoperoxide (2a) and nardoxide (3), were isolated from Nardostachys chinensis roots. Their structures were elucidated by spectral means. Among them, two endoperoxides, nardoperoxide (1a) and isonardoperoxide (2a), showed strong antimalarial activity against Plasmodium falciparum malaria (EC50 1.5 x 10-6 and 6.0 x 10-7 M, respectively).
| Original language | English |
|---|---|
| Pages (from-to) | 1361-1364 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 39 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Mar 12 1998 |
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ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
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Novel antimalarial guaiane-type sesquiterpenoids from Nardostachys chinensis roots. / Takaya, Yoshiaki; Kurumada, Ken Ichi; Takeuji, Yoshie; Kim, Hye-Sook; Shibata, Yasuharu; Ikemoto, Naomi; Wataya, Yusuke; Oshima, Yoshiteru.
In: Tetrahedron Letters, Vol. 39, No. 11, 12.03.1998, p. 1361-1364.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Novel antimalarial guaiane-type sesquiterpenoids from Nardostachys chinensis roots
AU - Takaya, Yoshiaki
AU - Kurumada, Ken Ichi
AU - Takeuji, Yoshie
AU - Kim, Hye-Sook
AU - Shibata, Yasuharu
AU - Ikemoto, Naomi
AU - Wataya, Yusuke
AU - Oshima, Yoshiteru
PY - 1998/3/12
Y1 - 1998/3/12
N2 - Three guaiane-type sesquiterpenoids, nardoperoxide (1a), isonardoperoxide (2a) and nardoxide (3), were isolated from Nardostachys chinensis roots. Their structures were elucidated by spectral means. Among them, two endoperoxides, nardoperoxide (1a) and isonardoperoxide (2a), showed strong antimalarial activity against Plasmodium falciparum malaria (EC50 1.5 x 10-6 and 6.0 x 10-7 M, respectively).
AB - Three guaiane-type sesquiterpenoids, nardoperoxide (1a), isonardoperoxide (2a) and nardoxide (3), were isolated from Nardostachys chinensis roots. Their structures were elucidated by spectral means. Among them, two endoperoxides, nardoperoxide (1a) and isonardoperoxide (2a), showed strong antimalarial activity against Plasmodium falciparum malaria (EC50 1.5 x 10-6 and 6.0 x 10-7 M, respectively).
UR - http://www.scopus.com/inward/record.url?scp=0032510297&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032510297&partnerID=8YFLogxK
U2 - 10.1016/S0040-4039(97)10844-9
DO - 10.1016/S0040-4039(97)10844-9
M3 - Article
AN - SCOPUS:0032510297
VL - 39
SP - 1361
EP - 1364
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 11
ER -