@article{3ee7e483c1d74eb8a4a2fd0e04632e35,
title = "Novel antimalarial guaiane-type sesquiterpenoids from Nardostachys chinensis roots",
abstract = "Three guaiane-type sesquiterpenoids, nardoperoxide (1a), isonardoperoxide (2a) and nardoxide (3), were isolated from Nardostachys chinensis roots. Their structures were elucidated by spectral means. Among them, two endoperoxides, nardoperoxide (1a) and isonardoperoxide (2a), showed strong antimalarial activity against Plasmodium falciparum malaria (EC50 1.5 x 10-6 and 6.0 x 10-7 M, respectively).",
author = "Yoshiaki Takaya and Kurumada, {Ken Ichi} and Yoshie Takeuji and Kim, {Hye Sook} and Yasuharu Shibata and Naomi Ikemoto and Yusuke Wataya and Yoshiteru Oshima",
note = "Funding Information: Acktwwledgemen!: This work was supported in part by a Grant-in Aid for Scientific Research on Priority Areas (No. 09270201 and No. d08281105) from the Ministry of Education, Science, Sports and Culture of Japan. Funding Information: formulas la and 2a. These results were supported by NOE experiment. Irradiation of H-6 of isonardoperoxide",
year = "1998",
month = mar,
day = "12",
doi = "10.1016/S0040-4039(97)10844-9",
language = "English",
volume = "39",
pages = "1361--1364",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "11",
}
