Novel and simple prognostic index for nasal natural killer/T-cell lymphoma

Hiroyuki Hanakawa; Yorihisa Orita; Yasuharu Sato; Soshi Takao; Hidenori Marunaka; Tokiwa Morishita; Yasuhiko Yamashita; Yasutaka Hori; Shuhei Domae; Ikuo Inokuchi; Seiko Akagi; Eisei Kondo; Noriko Iwaki; Kana Motomiya; Hirokazu Okumura; Tadashi Yoshino; Kazunori Nishizaki

doi:10.1002/hed.23322

Novel and simple prognostic index for nasal natural killer/T-cell lymphoma

Hiroyuki Hanakawa, Yorihisa Orita, Yasuharu Sato, Soshi Takao, Hidenori Marunaka, Tokiwa Morishita, Yasuhiko Yamashita, Yasutaka Hori, Shuhei Domae, Ikuo Inokuchi, Seiko Akagi, Eisei Kondo, Noriko Iwaki, Kana Motomiya, Hirokazu Okumura, Tadashi Yoshino, Kazunori Nishizaki

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Background Few studies have investigated the prognostic factors for nasal natural killer (NK)/T-cell lymphoma. Methods This was a retrospective multicenter clinical study. The clinical records of 36 patients with nasal NK/T-cell lymphoma who had been first treated between 1996 and 2011 were collected from 12 hospitals. Results High serum levels of C-reactive protein (≥1.0 mg/dL), lactate dehydrogenase (≥350 IU/L), and soluble interleukin-2 receptor (sIL-2R; ≥600 U/mL) were associated with worse prognosis. A prognostic score was devised by totaling the number of these 3 predictors: 0 or 1 = score 0; and 2 or 3 = score 1. As for tumor invasion, local invasion beyond the nasal cavity was associated with poor prognosis, and a prognostic score was devised as: tumor restricted to nasal cavity, yes = score 0; no = score 1. A novel prognostic index (NPI) was established based on these scores from 0 to 2. Disease-specific survival rates at 5 years were: 90.0% for NPI = 0; 29.3% for NPI = 1; and 0.0% for NPI = 2. Conclusion Our NPI is valid for anticipating prognosis of nasal NK/T-cell lymphoma.

Original language	English
Pages (from-to)	551-556
Number of pages	6
Journal	Head and Neck
Volume	36
Issue number	4
DOIs	https://doi.org/10.1002/hed.23322
Publication status	Published - Apr 2014

Keywords

blood examination
local invasion
nasal NK/T-cell lymphoma
prognosis
prognostic index

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.23322

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title = "Novel and simple prognostic index for nasal natural killer/T-cell lymphoma",

abstract = "Background Few studies have investigated the prognostic factors for nasal natural killer (NK)/T-cell lymphoma. Methods This was a retrospective multicenter clinical study. The clinical records of 36 patients with nasal NK/T-cell lymphoma who had been first treated between 1996 and 2011 were collected from 12 hospitals. Results High serum levels of C-reactive protein (≥1.0 mg/dL), lactate dehydrogenase (≥350 IU/L), and soluble interleukin-2 receptor (sIL-2R; ≥600 U/mL) were associated with worse prognosis. A prognostic score was devised by totaling the number of these 3 predictors: 0 or 1 = score 0; and 2 or 3 = score 1. As for tumor invasion, local invasion beyond the nasal cavity was associated with poor prognosis, and a prognostic score was devised as: tumor restricted to nasal cavity, yes = score 0; no = score 1. A novel prognostic index (NPI) was established based on these scores from 0 to 2. Disease-specific survival rates at 5 years were: 90.0% for NPI = 0; 29.3% for NPI = 1; and 0.0% for NPI = 2. Conclusion Our NPI is valid for anticipating prognosis of nasal NK/T-cell lymphoma.",

keywords = "blood examination, local invasion, nasal NK/T-cell lymphoma, prognosis, prognostic index",

author = "Hiroyuki Hanakawa and Yorihisa Orita and Yasuharu Sato and Soshi Takao and Hidenori Marunaka and Tokiwa Morishita and Yasuhiko Yamashita and Yasutaka Hori and Shuhei Domae and Ikuo Inokuchi and Seiko Akagi and Eisei Kondo and Noriko Iwaki and Kana Motomiya and Hirokazu Okumura and Tadashi Yoshino and Kazunori Nishizaki",

year = "2014",

month = apr,

doi = "10.1002/hed.23322",

language = "English",

volume = "36",

pages = "551--556",

journal = "Head and Neck",

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TY - JOUR

T1 - Novel and simple prognostic index for nasal natural killer/T-cell lymphoma

AU - Hanakawa, Hiroyuki

AU - Orita, Yorihisa

AU - Sato, Yasuharu

AU - Takao, Soshi

AU - Marunaka, Hidenori

AU - Morishita, Tokiwa

AU - Yamashita, Yasuhiko

AU - Hori, Yasutaka

AU - Domae, Shuhei

AU - Inokuchi, Ikuo

AU - Akagi, Seiko

AU - Kondo, Eisei

AU - Iwaki, Noriko

AU - Motomiya, Kana

AU - Okumura, Hirokazu

AU - Yoshino, Tadashi

AU - Nishizaki, Kazunori

PY - 2014/4

Y1 - 2014/4

N2 - Background Few studies have investigated the prognostic factors for nasal natural killer (NK)/T-cell lymphoma. Methods This was a retrospective multicenter clinical study. The clinical records of 36 patients with nasal NK/T-cell lymphoma who had been first treated between 1996 and 2011 were collected from 12 hospitals. Results High serum levels of C-reactive protein (≥1.0 mg/dL), lactate dehydrogenase (≥350 IU/L), and soluble interleukin-2 receptor (sIL-2R; ≥600 U/mL) were associated with worse prognosis. A prognostic score was devised by totaling the number of these 3 predictors: 0 or 1 = score 0; and 2 or 3 = score 1. As for tumor invasion, local invasion beyond the nasal cavity was associated with poor prognosis, and a prognostic score was devised as: tumor restricted to nasal cavity, yes = score 0; no = score 1. A novel prognostic index (NPI) was established based on these scores from 0 to 2. Disease-specific survival rates at 5 years were: 90.0% for NPI = 0; 29.3% for NPI = 1; and 0.0% for NPI = 2. Conclusion Our NPI is valid for anticipating prognosis of nasal NK/T-cell lymphoma.

AB - Background Few studies have investigated the prognostic factors for nasal natural killer (NK)/T-cell lymphoma. Methods This was a retrospective multicenter clinical study. The clinical records of 36 patients with nasal NK/T-cell lymphoma who had been first treated between 1996 and 2011 were collected from 12 hospitals. Results High serum levels of C-reactive protein (≥1.0 mg/dL), lactate dehydrogenase (≥350 IU/L), and soluble interleukin-2 receptor (sIL-2R; ≥600 U/mL) were associated with worse prognosis. A prognostic score was devised by totaling the number of these 3 predictors: 0 or 1 = score 0; and 2 or 3 = score 1. As for tumor invasion, local invasion beyond the nasal cavity was associated with poor prognosis, and a prognostic score was devised as: tumor restricted to nasal cavity, yes = score 0; no = score 1. A novel prognostic index (NPI) was established based on these scores from 0 to 2. Disease-specific survival rates at 5 years were: 90.0% for NPI = 0; 29.3% for NPI = 1; and 0.0% for NPI = 2. Conclusion Our NPI is valid for anticipating prognosis of nasal NK/T-cell lymphoma.

KW - blood examination

KW - local invasion

KW - nasal NK/T-cell lymphoma

KW - prognosis

KW - prognostic index

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JO - Head and Neck

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ER -

Novel and simple prognostic index for nasal natural killer/T-cell lymphoma

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