Novel and simple prognostic index for nasal natural killer/T-cell lymphoma

Hiroyuki Hanakawa, Yorihisa Orita, Yasuharu Sato, Soshi Takao, Hidenori Marunaka, Tokiwa Morishita, Yasuhiko Yamashita, Yasutaka Hori, Shuhei Domae, Ikuo Inokuchi, Seiko Akagi, Eisei Kondo, Noriko Iwaki, Kana Motomiya, Hirokazu Okumura, Tadashi Yoshino, Kazunori Nishizaki

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Background Few studies have investigated the prognostic factors for nasal natural killer (NK)/T-cell lymphoma. Methods This was a retrospective multicenter clinical study. The clinical records of 36 patients with nasal NK/T-cell lymphoma who had been first treated between 1996 and 2011 were collected from 12 hospitals. Results High serum levels of C-reactive protein (≥1.0 mg/dL), lactate dehydrogenase (≥350 IU/L), and soluble interleukin-2 receptor (sIL-2R; ≥600 U/mL) were associated with worse prognosis. A prognostic score was devised by totaling the number of these 3 predictors: 0 or 1 = score 0; and 2 or 3 = score 1. As for tumor invasion, local invasion beyond the nasal cavity was associated with poor prognosis, and a prognostic score was devised as: tumor restricted to nasal cavity, yes = score 0; no = score 1. A novel prognostic index (NPI) was established based on these scores from 0 to 2. Disease-specific survival rates at 5 years were: 90.0% for NPI = 0; 29.3% for NPI = 1; and 0.0% for NPI = 2. Conclusion Our NPI is valid for anticipating prognosis of nasal NK/T-cell lymphoma.

Original languageEnglish
Pages (from-to)551-556
Number of pages6
JournalHead and Neck
Issue number4
Publication statusPublished - Apr 2014


  • blood examination
  • local invasion
  • nasal NK/T-cell lymphoma
  • prognosis
  • prognostic index

ASJC Scopus subject areas

  • Otorhinolaryngology


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