Note Effects of Chlorpromazine and Estradiol Benzoate on Prolactin Secretion in Gonadectomized Male and Female Rats

Sumio Takahashi, Seiichiro Kawashima, Katsumi Wakabayashi

Research output: Contribution to journalArticle

3 Citations (Scopus)


Synopsis The effects of chlorpromazine (CPZ) and estradiol benzoate (EB) on serum prolactin (PRL) levels were studied in gonadectomized male and female rats. In both sexes CPZ (25 mg/kg body weight) produced an elevation of PRL when measured 2 hr after the injection, but the elevated levels were higher in ovariectomized rats than in orchidectomized rats. These results reconfirm a sexual difference in the regulatory mechanism of PRL secretion in response to the dopamine receptor blocker. Pretreatment with 5 µg EB 48 hr before CPZ injection abolished this sexual difference in serum PRL concentration.

Original languageEnglish
Pages (from-to)419-422
Number of pages4
JournalEndocrinologia Japonica
Issue number3
Publication statusPublished - Jan 1 1979
Externally publishedYes


ASJC Scopus subject areas

  • Endocrinology
  • Engineering(all)

Cite this