Notch signaling relieves the joint-suppressive activity of Defective proventriculus in the Drosophila leg

Tetsuya Shirai, Takeshi Yorimitsu, Naruto Kiritooshi, Fumio Matsuzaki, Hideki Nakagoshi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Segmentation plays crucial roles during morphogenesis. Drosophila legs are divided into segments along the proximal-distal axis by flexible structures called joints. Notch signaling is necessary and sufficient to promote leg growth and joint formation, and is activated in distal cells of each segment in everting prepupal leg discs. The homeobox gene defective proventriculus (dve) is expressed in regions both proximal and distal to the intersegmental folds at 4 h after puparium formation (APF). Dve-expressing region partly overlaps with the Notch-activated region, and they become a complementary pattern at 6 h APF. Interestingly, dve mutant legs resulted in extra joint formation at the center of each tarsal segment, and the forced expression of dve caused a jointless phenotype. We present evidence that Dve suppresses the potential joint-forming activity, and that Notch signaling represses Dve expression to form joints.

Original languageEnglish
Pages (from-to)147-156
Number of pages10
JournalDevelopmental Biology
Volume312
Issue number1
DOIs
Publication statusPublished - Dec 1 2007

Keywords

  • Drosophila
  • EGFR
  • Leg
  • Notch
  • Planar cell polarity
  • Segment
  • dve

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Notch signaling relieves the joint-suppressive activity of Defective proventriculus in the Drosophila leg'. Together they form a unique fingerprint.

  • Cite this