TY - JOUR
T1 - Notch signaling affects oral neoplasm cell differentiation and acquisition of tumor-specific characteristics
AU - Nakano, Keisuke
AU - Takabatake, Kiyofumi
AU - Kawai, Hotaka
AU - Yoshida, Saori
AU - Maeda, Hatsuhiko
AU - Kawakami, Toshiyuki
AU - Nagatsuka, Hitoshi
N1 - Funding Information:
Funding: This study was funded by the Japan Society for Promotion of Science (JSPS) KAKENHI (Nos. 16K11441, 17K11862, 18K09789, 18K17224).
PY - 2019/4/2
Y1 - 2019/4/2
N2 - Histopathological findings of oral neoplasm cell differentiation and metaplasia suggest that tumor cells induce their own dedifferentiation and re-differentiation and may lead to the formation of tumor-specific histological features. Notch signaling is involved in the maintenance of tissue stem cell nature and regulation of differentiation and is responsible for the cytological regulation of cell fate, morphogenesis, and/or development. In our previous study, immunohistochemistry was used to examine Notch expression using cases of odontogenic tumors and pleomorphic adenoma as oral neoplasms. According to our results, Notch signaling was specifically associated with tumor cell differentiation and metaplastic cells of developmental tissues. Notch signaling was involved in the differentiation of the ductal epithelial cells of salivary gland tumors and ameloblast-like cells of odontogenic tumors. However, Notch signaling was also involved in squamous metaplasia, irrespective of the type of developmental tissue. In odontogenic tumors, Notch signaling was involved in epithelial–mesenchymal interactions and may be related to tumor development and tumorigenesis. This signaling may also be associated with the malignant transformation of ameloblastomas. Overall, Notch signaling appears to play a major role in the formation of the characteristic cellular composition and histological features of oral neoplasms, and this involvement has been reviewed here.
AB - Histopathological findings of oral neoplasm cell differentiation and metaplasia suggest that tumor cells induce their own dedifferentiation and re-differentiation and may lead to the formation of tumor-specific histological features. Notch signaling is involved in the maintenance of tissue stem cell nature and regulation of differentiation and is responsible for the cytological regulation of cell fate, morphogenesis, and/or development. In our previous study, immunohistochemistry was used to examine Notch expression using cases of odontogenic tumors and pleomorphic adenoma as oral neoplasms. According to our results, Notch signaling was specifically associated with tumor cell differentiation and metaplastic cells of developmental tissues. Notch signaling was involved in the differentiation of the ductal epithelial cells of salivary gland tumors and ameloblast-like cells of odontogenic tumors. However, Notch signaling was also involved in squamous metaplasia, irrespective of the type of developmental tissue. In odontogenic tumors, Notch signaling was involved in epithelial–mesenchymal interactions and may be related to tumor development and tumorigenesis. This signaling may also be associated with the malignant transformation of ameloblastomas. Overall, Notch signaling appears to play a major role in the formation of the characteristic cellular composition and histological features of oral neoplasms, and this involvement has been reviewed here.
KW - Cell differentiation
KW - Epithelial-mesenchymal interaction
KW - Immunohistochemistry
KW - Malignant transformation
KW - Notch signaling
KW - Odontogenic tumor
KW - Pleomorphic adenoma
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U2 - 10.3390/ijms20081973
DO - 10.3390/ijms20081973
M3 - Review article
C2 - 31018488
AN - SCOPUS:85065335137
VL - 20
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 8
M1 - 1973
ER -