Nostofungicidine, an antifungal lipopeptide from the field-grown terrestrial blue-green alga Nostoc commune

Shin Ichiro Kajiyama, Hiroshi Kanzaki, Kazuyoshi Kawazu, Akio Kobayashi

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

In the course of our screening program for bioactive compounds, a novel lipopeptide, nostofungicidine (1), was isolated from the methanolic extract of a field-grown terrestrial blue-green alga, Nostoc commune. The structure of nostofungicidine was elucidated by chemical degradation and extensive NMR measurements including DQF-COSY, HOHAHA, HMBC, and ROESY techniques. Nostofungicidine contains a novel β-amino acid, 3-amino-6-hydroxy stearic acid (Ahs) in its structure.

Original languageEnglish
Pages (from-to)3737-3740
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number22
DOIs
Publication statusPublished - May 28 1998

Fingerprint

Nostoc commune
Lipopeptides
Cyanobacteria
Screening
Nuclear magnetic resonance
Amino Acids
Degradation
stearic acid

Keywords

  • Algae
  • Amino acid and derivatives
  • Antifungals
  • Natural products

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Nostofungicidine, an antifungal lipopeptide from the field-grown terrestrial blue-green alga Nostoc commune. / Kajiyama, Shin Ichiro; Kanzaki, Hiroshi; Kawazu, Kazuyoshi; Kobayashi, Akio.

In: Tetrahedron Letters, Vol. 39, No. 22, 28.05.1998, p. 3737-3740.

Research output: Contribution to journalArticle

Kajiyama, Shin Ichiro ; Kanzaki, Hiroshi ; Kawazu, Kazuyoshi ; Kobayashi, Akio. / Nostofungicidine, an antifungal lipopeptide from the field-grown terrestrial blue-green alga Nostoc commune. In: Tetrahedron Letters. 1998 ; Vol. 39, No. 22. pp. 3737-3740.
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