TY - JOUR
T1 - Nostodione A, a Novel Mitotic Spindle Poison* from a Blue-Green Alga Nostoc commune
AU - Kobayashi, Akio
AU - Kaiiyama, Shin ichiro
AU - Inawaka, Kunifumi
AU - Kanzaki, Hiroshi
AU - Kawazu, Kazuyoshi
N1 - Funding Information:
We are grateful to Mr. K. Godo (Ushimado Marine Laboratory, Faculty of Science, Okayama University) for the supply of sea-urchins, to Dr. K. Uneyama (Faculty of Technology, Okayama University) for the GC-MS measurement. The 500 MHz NMR spectra were measured at the SC-NMR Laboratory of Okayama University. This work was supported by Grant-in-Aid to A. Kobaya- shi for Scientific Research (No. 04252104) from the Ministry of Education. Science and Culture of Japan and by Nagase Science and Technology
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1994/8/1
Y1 - 1994/8/1
N2 - A, novel antimitotic compound named Nostodione A (Nd A) was isolated from a terrestrial blue-green alga Nostoc commune. Nostodione A disturbed the mitotic spindle formation of sea-urchin eggs and gave small spindles with low birefringence density. Nostodione, A. however, had no phytotoxicity on the germination of a dicotyledonous plant Medicago sativa. Based on the spectral analysis and chemical degradation, the structure of Nostodione A was elucidated.
AB - A, novel antimitotic compound named Nostodione A (Nd A) was isolated from a terrestrial blue-green alga Nostoc commune. Nostodione A disturbed the mitotic spindle formation of sea-urchin eggs and gave small spindles with low birefringence density. Nostodione, A. however, had no phytotoxicity on the germination of a dicotyledonous plant Medicago sativa. Based on the spectral analysis and chemical degradation, the structure of Nostodione A was elucidated.
KW - Blue-Green Alga
KW - Mitotic Spindle Poison
KW - Nostoc commune
KW - Nostodione, A
KW - Sea-Urchin Eggs
UR - http://www.scopus.com/inward/record.url?scp=0028011478&partnerID=8YFLogxK
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U2 - 10.1515/znc-1994-7-812
DO - 10.1515/znc-1994-7-812
M3 - Article
AN - SCOPUS:0028011478
VL - 49
SP - 464
EP - 470
JO - Zeitschrift fur Naturforschung. Teil C: Biochemie, Biophysik, Biologie, Virologie
JF - Zeitschrift fur Naturforschung. Teil C: Biochemie, Biophysik, Biologie, Virologie
SN - 0939-5075
IS - 7-8
ER -