Nostodione A, a Novel Mitotic Spindle Poison* from a Blue-Green Alga Nostoc commune

Akio Kobayashi; Shin ichiro Kaiiyama; Kunifumi Inawaka; Hiroshi Kanzaki; Kazuyoshi Kawazu

doi:10.1515/znc-1994-7-812

Nostodione A, a Novel Mitotic Spindle Poison* from a Blue-Green Alga Nostoc commune

Akio Kobayashi, Shin ichiro Kaiiyama, Kunifumi Inawaka, Hiroshi Kanzaki, Kazuyoshi Kawazu

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

A, novel antimitotic compound named Nostodione A (Nd A) was isolated from a terrestrial blue-green alga Nostoc commune. Nostodione A disturbed the mitotic spindle formation of sea-urchin eggs and gave small spindles with low birefringence density. Nostodione, A. however, had no phytotoxicity on the germination of a dicotyledonous plant Medicago sativa. Based on the spectral analysis and chemical degradation, the structure of Nostodione A was elucidated.

Original language	English
Pages (from-to)	464-470
Number of pages	7
Journal	Zeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume	49
Issue number	7-8
DOIs	https://doi.org/10.1515/znc-1994-7-812
Publication status	Published - Aug 1 1994

Keywords

Blue-Green Alga
Mitotic Spindle Poison
Nostoc commune
Nostodione, A
Sea-Urchin Eggs

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Nostodione A, a Novel Mitotic Spindle Poison* from a Blue-Green Alga Nostoc commune",

abstract = "A, novel antimitotic compound named Nostodione A (Nd A) was isolated from a terrestrial blue-green alga Nostoc commune. Nostodione A disturbed the mitotic spindle formation of sea-urchin eggs and gave small spindles with low birefringence density. Nostodione, A. however, had no phytotoxicity on the germination of a dicotyledonous plant Medicago sativa. Based on the spectral analysis and chemical degradation, the structure of Nostodione A was elucidated.",

keywords = "Blue-Green Alga, Mitotic Spindle Poison, Nostoc commune, Nostodione, A, Sea-Urchin Eggs",

author = "Akio Kobayashi and Kaiiyama, {Shin ichiro} and Kunifumi Inawaka and Hiroshi Kanzaki and Kazuyoshi Kawazu",

note = "Funding Information: We are grateful to Mr. K. Godo (Ushimado Marine Laboratory, Faculty of Science, Okayama University) for the supply of sea-urchins, to Dr. K. Uneyama (Faculty of Technology, Okayama University) for the GC-MS measurement. The 500 MHz NMR spectra were measured at the SC-NMR Laboratory of Okayama University. This work was supported by Grant-in-Aid to A. Kobaya- shi for Scientific Research (No. 04252104) from the Ministry of Education. Science and Culture of Japan and by Nagase Science and Technology",

year = "1994",

month = aug,

day = "1",

doi = "10.1515/znc-1994-7-812",

language = "English",

volume = "49",

pages = "464--470",

journal = "Zeitschrift fur Naturforschung. Section C: Biosciences",

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number = "7-8",

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TY - JOUR

T1 - Nostodione A, a Novel Mitotic Spindle Poison* from a Blue-Green Alga Nostoc commune

AU - Kobayashi, Akio

AU - Kaiiyama, Shin ichiro

AU - Inawaka, Kunifumi

AU - Kanzaki, Hiroshi

AU - Kawazu, Kazuyoshi

N1 - Funding Information: We are grateful to Mr. K. Godo (Ushimado Marine Laboratory, Faculty of Science, Okayama University) for the supply of sea-urchins, to Dr. K. Uneyama (Faculty of Technology, Okayama University) for the GC-MS measurement. The 500 MHz NMR spectra were measured at the SC-NMR Laboratory of Okayama University. This work was supported by Grant-in-Aid to A. Kobaya- shi for Scientific Research (No. 04252104) from the Ministry of Education. Science and Culture of Japan and by Nagase Science and Technology

PY - 1994/8/1

Y1 - 1994/8/1

N2 - A, novel antimitotic compound named Nostodione A (Nd A) was isolated from a terrestrial blue-green alga Nostoc commune. Nostodione A disturbed the mitotic spindle formation of sea-urchin eggs and gave small spindles with low birefringence density. Nostodione, A. however, had no phytotoxicity on the germination of a dicotyledonous plant Medicago sativa. Based on the spectral analysis and chemical degradation, the structure of Nostodione A was elucidated.

AB - A, novel antimitotic compound named Nostodione A (Nd A) was isolated from a terrestrial blue-green alga Nostoc commune. Nostodione A disturbed the mitotic spindle formation of sea-urchin eggs and gave small spindles with low birefringence density. Nostodione, A. however, had no phytotoxicity on the germination of a dicotyledonous plant Medicago sativa. Based on the spectral analysis and chemical degradation, the structure of Nostodione A was elucidated.

KW - Blue-Green Alga

KW - Mitotic Spindle Poison

KW - Nostoc commune

KW - Nostodione, A

KW - Sea-Urchin Eggs

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