Nostodione A, a Novel Mitotic Spindle Poison* from a Blue-Green Alga Nostoc commune

Akio Kobayashi, Shin ichiro Kaiiyama, Kunifumi Inawaka, Hiroshi Kanzaki, Kazuyoshi Kawazu

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

A, novel antimitotic compound named Nostodione A (Nd A) was isolated from a terrestrial blue-green alga Nostoc commune. Nostodione A disturbed the mitotic spindle formation of sea-urchin eggs and gave small spindles with low birefringence density. Nostodione, A. however, had no phytotoxicity on the germination of a dicotyledonous plant Medicago sativa. Based on the spectral analysis and chemical degradation, the structure of Nostodione A was elucidated.

Original languageEnglish
Pages (from-to)464-470
Number of pages7
JournalZeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume49
Issue number7-8
DOIs
Publication statusPublished - Aug 1 1994

Keywords

  • Blue-Green Alga
  • Mitotic Spindle Poison
  • Nostoc commune
  • Nostodione, A
  • Sea-Urchin Eggs

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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