Abstract
A 46-year-old man was found to have numerous cerebellar hemangioblastomas on magnetic resonance imaging (MRI). He denied any symptoms and had no history of hypertension, but his family history was remarkable for a father who died of renal cell carcinoma. Computed tomography (CT) of the abdomen revealed bilateral adrenal pheochromocytomas with significant enhancement in the regions where 131I-metaiodobenzylguanidine (MIBG) had noticeably accumulated. Endocrinological examinations demonstrated high plasma and urine catecholamine concentrations which were very responsive to metoclopramide and glucagon loading tests, without a significant change in blood pressure. After resection of bilateral pheochromocytomas, he underwent an operation for the cerebellar tumors. Since pheochromocytomas associated with Lindau or von Hippel-Lindau (VHL) disease have a tendency to multiple occurrence in normotensive patients, we suggest that patients with a family history involving VHL lesions should undergo cranial MRI, abdominal CT, MIBG scintigraphy and endocrinological examinations.
| Original language | English |
|---|---|
| Pages (from-to) | 719-723 |
| Number of pages | 5 |
| Journal | Endocrine Journal |
| Volume | 43 |
| Issue number | 6 |
| Publication status | Published - Dec 1996 |
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Keywords
- I-metaiodobenzylguanidine (MIBG)
- Cerebellar hemangioblastoma
- Glucagon
- Metoclopramide
- MRI
- Renal cell carcinoma
- Von Hippel-Lindau disease
ASJC Scopus subject areas
- Endocrinology
Cite this
Normotensive Bilateral Pheochromocytoma with Lindau Disease : Case Report. / Otsuka, Fumio; Ogura, Toshio; Nakagawa, Minoru; Hayakawa, Nobuhiko; Kataoka, Hideo; Oishi, Tetsuya; Makino, Hirofumi.
In: Endocrine Journal, Vol. 43, No. 6, 12.1996, p. 719-723.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Normotensive Bilateral Pheochromocytoma with Lindau Disease
T2 - Case Report
AU - Otsuka, Fumio
AU - Ogura, Toshio
AU - Nakagawa, Minoru
AU - Hayakawa, Nobuhiko
AU - Kataoka, Hideo
AU - Oishi, Tetsuya
AU - Makino, Hirofumi
PY - 1996/12
Y1 - 1996/12
N2 - A 46-year-old man was found to have numerous cerebellar hemangioblastomas on magnetic resonance imaging (MRI). He denied any symptoms and had no history of hypertension, but his family history was remarkable for a father who died of renal cell carcinoma. Computed tomography (CT) of the abdomen revealed bilateral adrenal pheochromocytomas with significant enhancement in the regions where 131I-metaiodobenzylguanidine (MIBG) had noticeably accumulated. Endocrinological examinations demonstrated high plasma and urine catecholamine concentrations which were very responsive to metoclopramide and glucagon loading tests, without a significant change in blood pressure. After resection of bilateral pheochromocytomas, he underwent an operation for the cerebellar tumors. Since pheochromocytomas associated with Lindau or von Hippel-Lindau (VHL) disease have a tendency to multiple occurrence in normotensive patients, we suggest that patients with a family history involving VHL lesions should undergo cranial MRI, abdominal CT, MIBG scintigraphy and endocrinological examinations.
AB - A 46-year-old man was found to have numerous cerebellar hemangioblastomas on magnetic resonance imaging (MRI). He denied any symptoms and had no history of hypertension, but his family history was remarkable for a father who died of renal cell carcinoma. Computed tomography (CT) of the abdomen revealed bilateral adrenal pheochromocytomas with significant enhancement in the regions where 131I-metaiodobenzylguanidine (MIBG) had noticeably accumulated. Endocrinological examinations demonstrated high plasma and urine catecholamine concentrations which were very responsive to metoclopramide and glucagon loading tests, without a significant change in blood pressure. After resection of bilateral pheochromocytomas, he underwent an operation for the cerebellar tumors. Since pheochromocytomas associated with Lindau or von Hippel-Lindau (VHL) disease have a tendency to multiple occurrence in normotensive patients, we suggest that patients with a family history involving VHL lesions should undergo cranial MRI, abdominal CT, MIBG scintigraphy and endocrinological examinations.
KW - I-metaiodobenzylguanidine (MIBG)
KW - Cerebellar hemangioblastoma
KW - Glucagon
KW - Metoclopramide
KW - MRI
KW - Renal cell carcinoma
KW - Von Hippel-Lindau disease
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UR - http://www.scopus.com/inward/citedby.url?scp=0030334847&partnerID=8YFLogxK
M3 - Article
C2 - 9075613
AN - SCOPUS:0030334847
VL - 43
SP - 719
EP - 723
JO - Endocrine Journal
JF - Endocrine Journal
SN - 0918-8959
IS - 6
ER -