Normotensive Bilateral Pheochromocytoma with Lindau Disease: Case Report

Fumio Otsuka, Toshio Ogura, Minoru Nakagawa, Nobuhiko Hayakawa, Hideo Kataoka, Tetsuya Oishi, Hirofumi Makino

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Abstract

A 46-year-old man was found to have numerous cerebellar hemangioblastomas on magnetic resonance imaging (MRI). He denied any symptoms and had no history of hypertension, but his family history was remarkable for a father who died of renal cell carcinoma. Computed tomography (CT) of the abdomen revealed bilateral adrenal pheochromocytomas with significant enhancement in the regions where 131I-metaiodobenzylguanidine (MIBG) had noticeably accumulated. Endocrinological examinations demonstrated high plasma and urine catecholamine concentrations which were very responsive to metoclopramide and glucagon loading tests, without a significant change in blood pressure. After resection of bilateral pheochromocytomas, he underwent an operation for the cerebellar tumors. Since pheochromocytomas associated with Lindau or von Hippel-Lindau (VHL) disease have a tendency to multiple occurrence in normotensive patients, we suggest that patients with a family history involving VHL lesions should undergo cranial MRI, abdominal CT, MIBG scintigraphy and endocrinological examinations.

Original languageEnglish
Pages (from-to)719-723
Number of pages5
JournalEndocrine journal
Volume43
Issue number6
DOIs
Publication statusPublished - Dec 1996

Keywords

  • Cerebellar hemangioblastoma
  • Glucagon
  • I-metaiodobenzylguanidine (MIBG)
  • MRI
  • Metoclopramide
  • Renal cell carcinoma
  • Von Hippel-Lindau disease

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Otsuka, F., Ogura, T., Nakagawa, M., Hayakawa, N., Kataoka, H., Oishi, T., & Makino, H. (1996). Normotensive Bilateral Pheochromocytoma with Lindau Disease: Case Report. Endocrine journal, 43(6), 719-723. https://doi.org/10.1507/endocrj.43.719