Normotensive Bilateral Pheochromocytoma with Lindau Disease: Case Report

Fumio Otsuka; Toshio Ogura; Minoru Nakagawa; Nobuhiko Hayakawa; Hideo Kataoka; Tetsuya Oishi; Hirofumi Makino

doi:10.1507/endocrj.43.719

Normotensive Bilateral Pheochromocytoma with Lindau Disease: Case Report

Fumio Otsuka, Toshio Ogura, Minoru Nakagawa, Nobuhiko Hayakawa, Hideo Kataoka, Tetsuya Oishi, Hirofumi Makino

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5 Citations (Scopus)

Abstract

A 46-year-old man was found to have numerous cerebellar hemangioblastomas on magnetic resonance imaging (MRI). He denied any symptoms and had no history of hypertension, but his family history was remarkable for a father who died of renal cell carcinoma. Computed tomography (CT) of the abdomen revealed bilateral adrenal pheochromocytomas with significant enhancement in the regions where ¹³¹I-metaiodobenzylguanidine (MIBG) had noticeably accumulated. Endocrinological examinations demonstrated high plasma and urine catecholamine concentrations which were very responsive to metoclopramide and glucagon loading tests, without a significant change in blood pressure. After resection of bilateral pheochromocytomas, he underwent an operation for the cerebellar tumors. Since pheochromocytomas associated with Lindau or von Hippel-Lindau (VHL) disease have a tendency to multiple occurrence in normotensive patients, we suggest that patients with a family history involving VHL lesions should undergo cranial MRI, abdominal CT, MIBG scintigraphy and endocrinological examinations.

Original language	English
Pages (from-to)	719-723
Number of pages	5
Journal	Endocrine journal
Volume	43
Issue number	6
DOIs	https://doi.org/10.1507/endocrj.43.719
Publication status	Published - Dec 1996

Keywords

Cerebellar hemangioblastoma
Glucagon
I-metaiodobenzylguanidine (MIBG)
MRI
Metoclopramide
Renal cell carcinoma
Von Hippel-Lindau disease

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1507/endocrj.43.719

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title = "Normotensive Bilateral Pheochromocytoma with Lindau Disease: Case Report",

abstract = "A 46-year-old man was found to have numerous cerebellar hemangioblastomas on magnetic resonance imaging (MRI). He denied any symptoms and had no history of hypertension, but his family history was remarkable for a father who died of renal cell carcinoma. Computed tomography (CT) of the abdomen revealed bilateral adrenal pheochromocytomas with significant enhancement in the regions where 131I-metaiodobenzylguanidine (MIBG) had noticeably accumulated. Endocrinological examinations demonstrated high plasma and urine catecholamine concentrations which were very responsive to metoclopramide and glucagon loading tests, without a significant change in blood pressure. After resection of bilateral pheochromocytomas, he underwent an operation for the cerebellar tumors. Since pheochromocytomas associated with Lindau or von Hippel-Lindau (VHL) disease have a tendency to multiple occurrence in normotensive patients, we suggest that patients with a family history involving VHL lesions should undergo cranial MRI, abdominal CT, MIBG scintigraphy and endocrinological examinations.",

keywords = "Cerebellar hemangioblastoma, Glucagon, I-metaiodobenzylguanidine (MIBG), MRI, Metoclopramide, Renal cell carcinoma, Von Hippel-Lindau disease",

author = "Fumio Otsuka and Toshio Ogura and Minoru Nakagawa and Nobuhiko Hayakawa and Hideo Kataoka and Tetsuya Oishi and Hirofumi Makino",

year = "1996",

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AU - Otsuka, Fumio

AU - Ogura, Toshio

AU - Nakagawa, Minoru

AU - Hayakawa, Nobuhiko

AU - Kataoka, Hideo

AU - Oishi, Tetsuya

AU - Makino, Hirofumi

PY - 1996/12

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N2 - A 46-year-old man was found to have numerous cerebellar hemangioblastomas on magnetic resonance imaging (MRI). He denied any symptoms and had no history of hypertension, but his family history was remarkable for a father who died of renal cell carcinoma. Computed tomography (CT) of the abdomen revealed bilateral adrenal pheochromocytomas with significant enhancement in the regions where 131I-metaiodobenzylguanidine (MIBG) had noticeably accumulated. Endocrinological examinations demonstrated high plasma and urine catecholamine concentrations which were very responsive to metoclopramide and glucagon loading tests, without a significant change in blood pressure. After resection of bilateral pheochromocytomas, he underwent an operation for the cerebellar tumors. Since pheochromocytomas associated with Lindau or von Hippel-Lindau (VHL) disease have a tendency to multiple occurrence in normotensive patients, we suggest that patients with a family history involving VHL lesions should undergo cranial MRI, abdominal CT, MIBG scintigraphy and endocrinological examinations.

AB - A 46-year-old man was found to have numerous cerebellar hemangioblastomas on magnetic resonance imaging (MRI). He denied any symptoms and had no history of hypertension, but his family history was remarkable for a father who died of renal cell carcinoma. Computed tomography (CT) of the abdomen revealed bilateral adrenal pheochromocytomas with significant enhancement in the regions where 131I-metaiodobenzylguanidine (MIBG) had noticeably accumulated. Endocrinological examinations demonstrated high plasma and urine catecholamine concentrations which were very responsive to metoclopramide and glucagon loading tests, without a significant change in blood pressure. After resection of bilateral pheochromocytomas, he underwent an operation for the cerebellar tumors. Since pheochromocytomas associated with Lindau or von Hippel-Lindau (VHL) disease have a tendency to multiple occurrence in normotensive patients, we suggest that patients with a family history involving VHL lesions should undergo cranial MRI, abdominal CT, MIBG scintigraphy and endocrinological examinations.

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Normotensive Bilateral Pheochromocytoma with Lindau Disease: Case Report

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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