Nontumorous decrease in Tc-99m GSA accumulation

S. Akaki, Susumu Kanazawa, M. Tsunoda, Y. Okumura, I. Togami, Masahiro Kuroda, Yoshihiro Takeda, Y. Hiraki

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Nontumorous decrease in 99mTc-GSA accumulation has not been well covered in the literature. Understanding of this phenomenon is, however, essential for accurate evaluation of regional hepatic function. Scintigrams (transaxial SPECT) of 269 patients who underwent 99mTc-GSA liver scintigraphy were reviewed for the presence of nontumorous decreases in 99mTc-GSA accumulation. Nontumorous decreases in 99mTc-GSA accumulation were seen in 32 of 269 patients (12%). In 16 of the 32 patients (6%), nontumorous decreases in 99mTc-GSA accumulation corresponded to regional decrease in portal venous flow. The causes of such decrease in portal venous flow were portal thrombus of hepatocellular carcinomas in eight patients, portal venous stenosis or occlusion by hilar cholangiocarcinomas in five patients, inter alia. In eight patients (3%), the regions with decreased 99mTc-GSA accumulation correlated with massive hepatic necrosis in fulminant hepatitis, scar in hepatitis, or confluent fibrosis in cirrhotic liver. In two patients (0.7%) with hilar cholangiocarcinomas, the possible causes of lobar decrease in 99mTc-GSA accumulation were thought to be lobar decrease in portal venous flow, lobar biliary stasis, or both. In four patients (1.5%), the exact causes of nontumorous decrease in 99mTc-GSA accumulation could not be determined.

Original languageEnglish
Pages (from-to)477-483
Number of pages7
JournalAnnals of Nuclear Medicine
Volume14
Issue number6
Publication statusPublished - 2000

Fingerprint

Klatskin Tumor
Hepatitis
Liver
Massive Hepatic Necrosis
Cholestasis
technetium Tc 99m DTPA-galactosyl-human serum albumin
Single-Photon Emission-Computed Tomography
Radionuclide Imaging
Cicatrix
Hepatocellular Carcinoma
Pathologic Constriction
Thrombosis
Fibrosis

Keywords

  • Liver
  • Portal venous flow decrease
  • Technetium-99m GSA

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Akaki, S., Kanazawa, S., Tsunoda, M., Okumura, Y., Togami, I., Kuroda, M., ... Hiraki, Y. (2000). Nontumorous decrease in Tc-99m GSA accumulation. Annals of Nuclear Medicine, 14(6), 477-483.

Nontumorous decrease in Tc-99m GSA accumulation. / Akaki, S.; Kanazawa, Susumu; Tsunoda, M.; Okumura, Y.; Togami, I.; Kuroda, Masahiro; Takeda, Yoshihiro; Hiraki, Y.

In: Annals of Nuclear Medicine, Vol. 14, No. 6, 2000, p. 477-483.

Research output: Contribution to journalArticle

Akaki, S, Kanazawa, S, Tsunoda, M, Okumura, Y, Togami, I, Kuroda, M, Takeda, Y & Hiraki, Y 2000, 'Nontumorous decrease in Tc-99m GSA accumulation', Annals of Nuclear Medicine, vol. 14, no. 6, pp. 477-483.
Akaki S, Kanazawa S, Tsunoda M, Okumura Y, Togami I, Kuroda M et al. Nontumorous decrease in Tc-99m GSA accumulation. Annals of Nuclear Medicine. 2000;14(6):477-483.
Akaki, S. ; Kanazawa, Susumu ; Tsunoda, M. ; Okumura, Y. ; Togami, I. ; Kuroda, Masahiro ; Takeda, Yoshihiro ; Hiraki, Y. / Nontumorous decrease in Tc-99m GSA accumulation. In: Annals of Nuclear Medicine. 2000 ; Vol. 14, No. 6. pp. 477-483.
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