Nonspecificity Induces Chiral Specificity in the Folding Transition of Giant DNA

Michiko Ito; Akira Sakakura; Naomi Miyazawa; Shizuaki Murata; Kenichi Yoshikawa

doi:10.1021/ja036745x

Nonspecificity Induces Chiral Specificity in the Folding Transition of Giant DNA

Michiko Ito, Akira Sakakura, Naomi Miyazawa, Shizuaki Murata, Kenichi Yoshikawa

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The all-or-none type DNA folding transition from a coil to globule can be differentiated by the chirality of the triamines. The fluorescent microscope observation on single DNA molecules makes it clear that the tripeptides obtained from naturally occurring basic amino acids (L-lysine or L-arginine) can compact DNA molecules at concentrations lower than those from D-isomers. Nanometer-sized beads are found in the AFM images on the folded DNA molecule.

Original language	English
Pages (from-to)	12714-12715
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	125
Issue number	42
DOIs	https://doi.org/10.1021/ja036745x
Publication status	Published - Oct 22 2003
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja036745x

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abstract = "The all-or-none type DNA folding transition from a coil to globule can be differentiated by the chirality of the triamines. The fluorescent microscope observation on single DNA molecules makes it clear that the tripeptides obtained from naturally occurring basic amino acids (L-lysine or L-arginine) can compact DNA molecules at concentrations lower than those from D-isomers. Nanometer-sized beads are found in the AFM images on the folded DNA molecule.",

author = "Michiko Ito and Akira Sakakura and Naomi Miyazawa and Shizuaki Murata and Kenichi Yoshikawa",

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AU - Sakakura, Akira

AU - Miyazawa, Naomi

AU - Murata, Shizuaki

AU - Yoshikawa, Kenichi

PY - 2003/10/22

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AB - The all-or-none type DNA folding transition from a coil to globule can be differentiated by the chirality of the triamines. The fluorescent microscope observation on single DNA molecules makes it clear that the tripeptides obtained from naturally occurring basic amino acids (L-lysine or L-arginine) can compact DNA molecules at concentrations lower than those from D-isomers. Nanometer-sized beads are found in the AFM images on the folded DNA molecule.

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Nonspecificity Induces Chiral Specificity in the Folding Transition of Giant DNA

Abstract

ASJC Scopus subject areas

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