Nonspecificity Induces Chiral Specificity in the Folding Transition of Giant DNA

Michiko Ito, Akira Sakakura, Naomi Miyazawa, Shizuaki Murata, Kenichi Yoshikawa

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


The all-or-none type DNA folding transition from a coil to globule can be differentiated by the chirality of the triamines. The fluorescent microscope observation on single DNA molecules makes it clear that the tripeptides obtained from naturally occurring basic amino acids (L-lysine or L-arginine) can compact DNA molecules at concentrations lower than those from D-isomers. Nanometer-sized beads are found in the AFM images on the folded DNA molecule.

Original languageEnglish
Pages (from-to)12714-12715
Number of pages2
JournalJournal of the American Chemical Society
Issue number42
Publication statusPublished - Oct 22 2003
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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