Nonspecificity Induces Chiral Specificity in the Folding Transition of Giant DNA

Michiko Ito, Akira Sakakura, Naomi Miyazawa, Shizuaki Murata, Kenichi Yoshikawa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The all-or-none type DNA folding transition from a coil to globule can be differentiated by the chirality of the triamines. The fluorescent microscope observation on single DNA molecules makes it clear that the tripeptides obtained from naturally occurring basic amino acids (L-lysine or L-arginine) can compact DNA molecules at concentrations lower than those from D-isomers. Nanometer-sized beads are found in the AFM images on the folded DNA molecule.

Original languageEnglish
Pages (from-to)12714-12715
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number42
DOIs
Publication statusPublished - Oct 22 2003
Externally publishedYes

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DNA
Molecules
Basic Amino Acids
Arginine
Chirality
Isomers
Lysine
Amino acids
Microscopes

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Nonspecificity Induces Chiral Specificity in the Folding Transition of Giant DNA. / Ito, Michiko; Sakakura, Akira; Miyazawa, Naomi; Murata, Shizuaki; Yoshikawa, Kenichi.

In: Journal of the American Chemical Society, Vol. 125, No. 42, 22.10.2003, p. 12714-12715.

Research output: Contribution to journalArticle

Ito, Michiko ; Sakakura, Akira ; Miyazawa, Naomi ; Murata, Shizuaki ; Yoshikawa, Kenichi. / Nonspecificity Induces Chiral Specificity in the Folding Transition of Giant DNA. In: Journal of the American Chemical Society. 2003 ; Vol. 125, No. 42. pp. 12714-12715.
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