Non-viral gene delivery regulated by stiffness of cell adhesion substrates

Hyun Joon Kong, Jodi Liu, Kathryn Riddle, Takuya Matsumoto, Kent Leach, David J. Mooney

Research output: Contribution to journalArticlepeer-review

194 Citations (Scopus)

Abstract

The rigidity of the cell adhesion substrate on the level of gene transfer and expression, was investigated. Gene-transfer efficiency was investigated using a fluorescent resonance energy transfer (FRET) technique, as FRET techniques have been extensively used to evaluate specific intermolecular interactions at the nanometre scale. The mechanical properties of the substrate to which cell adheres have been found to mediate many aspects of cell function including proliferation, migration and differentiations. The study indicated the importance of material mechanics in regulating gene transfer and expression, and also enabled to understand the gene transfer processes in different tissues.

Original languageEnglish
Pages (from-to)460-464
Number of pages5
JournalNature Materials
Volume4
Issue number6
DOIs
Publication statusPublished - Jun 2005
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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