Non-invasive measurement of brachial-ankle pulse wave velocity is associated with serum C-reactive protein but not with α-tocopherol in Japanese middle-aged male workers

Tomonori Okamura, Yuri Moriyama, Takashi Kadowaki, Hideyuki Kanda, Hirotsugu Ueshima

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Pulse wave velocity (PWV) is an indicator of arterial stiffness, especially in the aorta, and a marker for vascular damage. We examined the association of brachial-ankle PWV (baPWV) with serum α-tocopherol and C-reactive protein (CRP) levels in addition to the traditional risk factors. Study subjects were 178 Japanese male workers aged 50-59 without past histories of cardiovascular diseases. The relation of baPWV with serum α-tocopherol and CRP levels was cross-sectionally analyzed after adjusting for other cardiovascular risk factors. The arithmetic mean of serum α-tocopherol was 38.9 μmol/l, and the geometric mean of serum CRP was 0.47 mg/l. Multiple linear regression analysis indicated that serum CRP levels were associated with an elevation of baPWV, in addition to age, systolic blood pressure and heart rate. However, serum α-tocopherol, serum lipids (triglyceride, low and high density lipoprotein cholesterol), fasting plasma glucose, body mass index, smoking and alcohol drinking did not significantly correlate to baPWV. Multivariate-adjusted means of baPWV according to serum CRP quartile were 1,431, 1,436, 1,507 and 1,508 cm/s (p=0.033). The serum CRP level might be an important marker for arterial stiffness in Japanese middle-aged males. However, no relation was observed between α-tocopherol and baPWV.

Original languageEnglish
Pages (from-to)173-180
Number of pages8
JournalHypertension Research
Volume27
Issue number3
DOIs
Publication statusPublished - Mar 1 2004
Externally publishedYes

Fingerprint

Pulse Wave Analysis
Tocopherols
Ankle
C-Reactive Protein
Blood Proteins
Arm
Serum
Vascular Stiffness
Blood Pressure
Alcohol Drinking
LDL Cholesterol
HDL Cholesterol
Blood Vessels
Aorta
Linear Models
Fasting
Triglycerides
Body Mass Index
Cardiovascular Diseases
Heart Rate

Keywords

  • α-tocopherol
  • C-reactive protein
  • Pulse wave velocity
  • Risk factors

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Non-invasive measurement of brachial-ankle pulse wave velocity is associated with serum C-reactive protein but not with α-tocopherol in Japanese middle-aged male workers. / Okamura, Tomonori; Moriyama, Yuri; Kadowaki, Takashi; Kanda, Hideyuki; Ueshima, Hirotsugu.

In: Hypertension Research, Vol. 27, No. 3, 01.03.2004, p. 173-180.

Research output: Contribution to journalArticle

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