Non-destructive evaluation method of pharmaceutical tablet by terahertz-time-domain spectroscopy: Application to sound-alike medicines

Masaya Kawase, Kohji Yamamoto, Keita Takagi, Ryohei Yasuda, Masafumi Ogawa, Yasutoshi Hatsuda, Sonoyo Kawanishi, Yoshihiko Hirotani, Michiaki Myotoku, Yoko Urashima, Katsuhito Nagai, Kenji Ikeda, Hiroki Konishi, Junji Yamakawa, Masahiko Tani

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

To evaluate terahertz time-domain spectroscopy (THz-TDS) as a promising tool for discriminating pharmaceutical tablets, THz-TDS has been applied for discrimination between pharmaceutical tablets with sound-alike names. Two sets of medicine tablets with sound-alike names, that is, Amaryl and Almarl, Zyloric and Zantac, are examined in this study. Based on the difference in THz absorption spectra, we have succeeded in distinguishing between sound-alike medicine tablets clearly for each set. The results in this study suggest that THz-TDS is a useful tool that is indispensable for medical security maintenance, such as a non-destructive way to prevent mix-up of medicine.

Original languageEnglish
Pages (from-to)566-571
Number of pages6
JournalJournal of Infrared, Millimeter, and Terahertz Waves
Volume34
Issue number9
DOIs
Publication statusPublished - Sep 2013

Fingerprint

tablets
medicine
Drug products
Medicine
Acoustic waves
Spectroscopy
acoustics
evaluation
spectroscopy
Absorption spectra
maintenance
discrimination
absorption spectra

Keywords

  • Medical security maintenance
  • Non-destructive method
  • Pharmaceutical tablet
  • Sound-alike medicine
  • THz-TDS

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics
  • Radiation
  • Instrumentation

Cite this

Non-destructive evaluation method of pharmaceutical tablet by terahertz-time-domain spectroscopy : Application to sound-alike medicines. / Kawase, Masaya; Yamamoto, Kohji; Takagi, Keita; Yasuda, Ryohei; Ogawa, Masafumi; Hatsuda, Yasutoshi; Kawanishi, Sonoyo; Hirotani, Yoshihiko; Myotoku, Michiaki; Urashima, Yoko; Nagai, Katsuhito; Ikeda, Kenji; Konishi, Hiroki; Yamakawa, Junji; Tani, Masahiko.

In: Journal of Infrared, Millimeter, and Terahertz Waves, Vol. 34, No. 9, 09.2013, p. 566-571.

Research output: Contribution to journalArticle

Kawase, M, Yamamoto, K, Takagi, K, Yasuda, R, Ogawa, M, Hatsuda, Y, Kawanishi, S, Hirotani, Y, Myotoku, M, Urashima, Y, Nagai, K, Ikeda, K, Konishi, H, Yamakawa, J & Tani, M 2013, 'Non-destructive evaluation method of pharmaceutical tablet by terahertz-time-domain spectroscopy: Application to sound-alike medicines', Journal of Infrared, Millimeter, and Terahertz Waves, vol. 34, no. 9, pp. 566-571. https://doi.org/10.1007/s10762-013-9994-2
Kawase, Masaya ; Yamamoto, Kohji ; Takagi, Keita ; Yasuda, Ryohei ; Ogawa, Masafumi ; Hatsuda, Yasutoshi ; Kawanishi, Sonoyo ; Hirotani, Yoshihiko ; Myotoku, Michiaki ; Urashima, Yoko ; Nagai, Katsuhito ; Ikeda, Kenji ; Konishi, Hiroki ; Yamakawa, Junji ; Tani, Masahiko. / Non-destructive evaluation method of pharmaceutical tablet by terahertz-time-domain spectroscopy : Application to sound-alike medicines. In: Journal of Infrared, Millimeter, and Terahertz Waves. 2013 ; Vol. 34, No. 9. pp. 566-571.
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