Non-alcoholic fatty liver disease in patients with autoimmune hepatitis

Japan AIH Study Group (JAIHSG)

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background and Aim: The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing all over the world. NAFLD develops in patients with liver disease, including patients with autoimmune hepatitis (AIH). NAFLD and AIH have some similar laboratory and histological findings. The aim of this study was to elucidate the characteristics of AIH patients with NAFLD. Methods: We re-evaluated the nationwide survey performed in Japan in 2015 of AIH patients diagnosed between 2009 and 2013. Results: A total of 1151 subjects (144 men and 1007 women) were enrolled in the present study. The overall prevalence of NAFLD was 17.0%. Compared to AIH without NAFLD, AIH patients with NAFLD had the following characteristics: (i) low female-to-male ratio, (ii) older age, (iii) mild elevation in hepatobiliary enzymes, (iv) histologically progressive fibrosis and mild plasma cell infiltration or mild lobular hepatitis, (v) lower prevalence of prednisolone administration and higher prevalence of ursodeoxycholic acid administration, (vi) higher levels of hepatic enzymes and immunoglobulin G after treatment, and (vii) similar prevalence of autoimmune and malignant complications. Conclusion: AIH patients with NAFLD have many features that are different from AIH patients without NAFLD. Understanding these differences is essential for the proper diagnosis and treatment of AIH patients with NAFLD.

Original languageEnglish
Pages (from-to)54-58
Number of pages5
JournalJGH Open
Volume2
Issue number2
DOIs
Publication statusPublished - Apr 1 2018

Fingerprint

Autoimmune Hepatitis
Non-alcoholic Fatty Liver Disease
Ursodeoxycholic Acid
Enzymes
Prednisolone
Plasma Cells
Hepatitis
Liver Diseases
Japan
Fibrosis
Immunoglobulin G

Keywords

  • autoimmune hepatitis
  • laboratory findings
  • liver histological findings
  • nationwide survey
  • non-alcoholic fatty liver disease
  • treatment

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Non-alcoholic fatty liver disease in patients with autoimmune hepatitis. / Japan AIH Study Group (JAIHSG).

In: JGH Open, Vol. 2, No. 2, 01.04.2018, p. 54-58.

Research output: Contribution to journalArticle

Japan AIH Study Group (JAIHSG). / Non-alcoholic fatty liver disease in patients with autoimmune hepatitis. In: JGH Open. 2018 ; Vol. 2, No. 2. pp. 54-58.
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title = "Non-alcoholic fatty liver disease in patients with autoimmune hepatitis",
abstract = "Background and Aim: The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing all over the world. NAFLD develops in patients with liver disease, including patients with autoimmune hepatitis (AIH). NAFLD and AIH have some similar laboratory and histological findings. The aim of this study was to elucidate the characteristics of AIH patients with NAFLD. Methods: We re-evaluated the nationwide survey performed in Japan in 2015 of AIH patients diagnosed between 2009 and 2013. Results: A total of 1151 subjects (144 men and 1007 women) were enrolled in the present study. The overall prevalence of NAFLD was 17.0{\%}. Compared to AIH without NAFLD, AIH patients with NAFLD had the following characteristics: (i) low female-to-male ratio, (ii) older age, (iii) mild elevation in hepatobiliary enzymes, (iv) histologically progressive fibrosis and mild plasma cell infiltration or mild lobular hepatitis, (v) lower prevalence of prednisolone administration and higher prevalence of ursodeoxycholic acid administration, (vi) higher levels of hepatic enzymes and immunoglobulin G after treatment, and (vii) similar prevalence of autoimmune and malignant complications. Conclusion: AIH patients with NAFLD have many features that are different from AIH patients without NAFLD. Understanding these differences is essential for the proper diagnosis and treatment of AIH patients with NAFLD.",
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author = "{Japan AIH Study Group (JAIHSG)} and Atsushi Takahashi and Teruko Arinaga-Hino and Hiromasa Ohira and Kazumichi Abe and Takuji Torimura and Mikio Zeniya and Masanori Abe and Kaname Yoshizawa and Akinobu Takaki and Yoshiyuki Suzuki and Kang, {Jong Hon} and Nobuhiro Nakamoto and Tomoo Fujisawa and Atsushi Tanaka and Hajime Takikawa",
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AU - Japan AIH Study Group (JAIHSG)

AU - Takahashi, Atsushi

AU - Arinaga-Hino, Teruko

AU - Ohira, Hiromasa

AU - Abe, Kazumichi

AU - Torimura, Takuji

AU - Zeniya, Mikio

AU - Abe, Masanori

AU - Yoshizawa, Kaname

AU - Takaki, Akinobu

AU - Suzuki, Yoshiyuki

AU - Kang, Jong Hon

AU - Nakamoto, Nobuhiro

AU - Fujisawa, Tomoo

AU - Tanaka, Atsushi

AU - Takikawa, Hajime

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N2 - Background and Aim: The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing all over the world. NAFLD develops in patients with liver disease, including patients with autoimmune hepatitis (AIH). NAFLD and AIH have some similar laboratory and histological findings. The aim of this study was to elucidate the characteristics of AIH patients with NAFLD. Methods: We re-evaluated the nationwide survey performed in Japan in 2015 of AIH patients diagnosed between 2009 and 2013. Results: A total of 1151 subjects (144 men and 1007 women) were enrolled in the present study. The overall prevalence of NAFLD was 17.0%. Compared to AIH without NAFLD, AIH patients with NAFLD had the following characteristics: (i) low female-to-male ratio, (ii) older age, (iii) mild elevation in hepatobiliary enzymes, (iv) histologically progressive fibrosis and mild plasma cell infiltration or mild lobular hepatitis, (v) lower prevalence of prednisolone administration and higher prevalence of ursodeoxycholic acid administration, (vi) higher levels of hepatic enzymes and immunoglobulin G after treatment, and (vii) similar prevalence of autoimmune and malignant complications. Conclusion: AIH patients with NAFLD have many features that are different from AIH patients without NAFLD. Understanding these differences is essential for the proper diagnosis and treatment of AIH patients with NAFLD.

AB - Background and Aim: The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing all over the world. NAFLD develops in patients with liver disease, including patients with autoimmune hepatitis (AIH). NAFLD and AIH have some similar laboratory and histological findings. The aim of this study was to elucidate the characteristics of AIH patients with NAFLD. Methods: We re-evaluated the nationwide survey performed in Japan in 2015 of AIH patients diagnosed between 2009 and 2013. Results: A total of 1151 subjects (144 men and 1007 women) were enrolled in the present study. The overall prevalence of NAFLD was 17.0%. Compared to AIH without NAFLD, AIH patients with NAFLD had the following characteristics: (i) low female-to-male ratio, (ii) older age, (iii) mild elevation in hepatobiliary enzymes, (iv) histologically progressive fibrosis and mild plasma cell infiltration or mild lobular hepatitis, (v) lower prevalence of prednisolone administration and higher prevalence of ursodeoxycholic acid administration, (vi) higher levels of hepatic enzymes and immunoglobulin G after treatment, and (vii) similar prevalence of autoimmune and malignant complications. Conclusion: AIH patients with NAFLD have many features that are different from AIH patients without NAFLD. Understanding these differences is essential for the proper diagnosis and treatment of AIH patients with NAFLD.

KW - autoimmune hepatitis

KW - laboratory findings

KW - liver histological findings

KW - nationwide survey

KW - non-alcoholic fatty liver disease

KW - treatment

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