Nodal T/NK-cell lymphoma of nasal type: A clinicopathological study of six cases

E. Takahashi, N. Asano, C. Li, Takehiro Tanaka, K. Shimada, S. Shimada, Tadashi Yoshino, M. Kojima, K. Hara, T. Eimoto, S. Nakamura

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Abstract

Aims: To investigate the clinicopathological features of six unusual cases of nodal CD56+ and Epstein-Barr virus (EBV)+ T/natural killer (NK)-cell lymphoma, a putative nodal counterpart of nasal NK/T-cell lymphoma (nodal T/NK-cell lymphoma of nasal type) in comparison with nasal NK/T-cell lymphoma with secondary lymph node involvement (n = 24) and peripheral T-cell lymphoma (PTCL) of cytotoxic molecule (CTM)+ and EBV+ type (n = 21). Methods and results: All cases of nodal T/NK-cell lymphoma of nasal type exhibited diffuse infiltration of pleomorphic medium-sized to large tumour cells, reminiscent of those in CTM+ EBV+ PTCL. The tumour cells had a typical phenotype of nasal NK/T-cell lymphoma: CD2+, CD3ε+, CD4-, CD5-, CD56+, T-cell intracellular antigen-1+, granzyme B+, perforin+ and EBV+. However, four of six cases demonstrated clonal T-cell receptor γ-gene rearrangement on polymerase chain reaction analysis, unlike nasal NK/T-cell lymphoma. Comparison of clinical parameters and overall survival among the three groups demonstrated only minor differences. Conclusions: Nodal T/NK-cell lymphoma may occupy the grey zone between extranodal nasal-type NK/T-cell lymphoma and nodal CTM+ PTCL in a spectrum of NK to T-cell lymphomas that are EBV+. The close relationship between NK/T-cell lymphomas and cytotoxic T-cell lymphomas was also substantiated.

Original languageEnglish
Pages (from-to)585-596
Number of pages12
JournalHistopathology
Volume52
Issue number5
DOIs
Publication statusPublished - Apr 2008

Fingerprint

Natural Killer T-Cells
Nose
Lymphoma
T-Cell Lymphoma
Human Herpesvirus 4
Peripheral T-Cell Lymphoma
T-Lymphocyte Gene Rearrangement
T-Cell Receptor Genes
Neoplasms
Lymph Nodes

Keywords

  • Cytotoxic phenotype
  • Epstein-Barr virus
  • NK/T-cell lymphoma
  • Nodal peripheral T-cell lymphoma
  • TCRγ rearrangement

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

Takahashi, E., Asano, N., Li, C., Tanaka, T., Shimada, K., Shimada, S., ... Nakamura, S. (2008). Nodal T/NK-cell lymphoma of nasal type: A clinicopathological study of six cases. Histopathology, 52(5), 585-596. https://doi.org/10.1111/j.1365-2559.2008.02997.x

Nodal T/NK-cell lymphoma of nasal type : A clinicopathological study of six cases. / Takahashi, E.; Asano, N.; Li, C.; Tanaka, Takehiro; Shimada, K.; Shimada, S.; Yoshino, Tadashi; Kojima, M.; Hara, K.; Eimoto, T.; Nakamura, S.

In: Histopathology, Vol. 52, No. 5, 04.2008, p. 585-596.

Research output: Contribution to journalArticle

Takahashi, E, Asano, N, Li, C, Tanaka, T, Shimada, K, Shimada, S, Yoshino, T, Kojima, M, Hara, K, Eimoto, T & Nakamura, S 2008, 'Nodal T/NK-cell lymphoma of nasal type: A clinicopathological study of six cases', Histopathology, vol. 52, no. 5, pp. 585-596. https://doi.org/10.1111/j.1365-2559.2008.02997.x
Takahashi, E. ; Asano, N. ; Li, C. ; Tanaka, Takehiro ; Shimada, K. ; Shimada, S. ; Yoshino, Tadashi ; Kojima, M. ; Hara, K. ; Eimoto, T. ; Nakamura, S. / Nodal T/NK-cell lymphoma of nasal type : A clinicopathological study of six cases. In: Histopathology. 2008 ; Vol. 52, No. 5. pp. 585-596.
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AU - Li, C.

AU - Tanaka, Takehiro

AU - Shimada, K.

AU - Shimada, S.

AU - Yoshino, Tadashi

AU - Kojima, M.

AU - Hara, K.

AU - Eimoto, T.

AU - Nakamura, S.

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N2 - Aims: To investigate the clinicopathological features of six unusual cases of nodal CD56+ and Epstein-Barr virus (EBV)+ T/natural killer (NK)-cell lymphoma, a putative nodal counterpart of nasal NK/T-cell lymphoma (nodal T/NK-cell lymphoma of nasal type) in comparison with nasal NK/T-cell lymphoma with secondary lymph node involvement (n = 24) and peripheral T-cell lymphoma (PTCL) of cytotoxic molecule (CTM)+ and EBV+ type (n = 21). Methods and results: All cases of nodal T/NK-cell lymphoma of nasal type exhibited diffuse infiltration of pleomorphic medium-sized to large tumour cells, reminiscent of those in CTM+ EBV+ PTCL. The tumour cells had a typical phenotype of nasal NK/T-cell lymphoma: CD2+, CD3ε+, CD4-, CD5-, CD56+, T-cell intracellular antigen-1+, granzyme B+, perforin+ and EBV+. However, four of six cases demonstrated clonal T-cell receptor γ-gene rearrangement on polymerase chain reaction analysis, unlike nasal NK/T-cell lymphoma. Comparison of clinical parameters and overall survival among the three groups demonstrated only minor differences. Conclusions: Nodal T/NK-cell lymphoma may occupy the grey zone between extranodal nasal-type NK/T-cell lymphoma and nodal CTM+ PTCL in a spectrum of NK to T-cell lymphomas that are EBV+. The close relationship between NK/T-cell lymphomas and cytotoxic T-cell lymphomas was also substantiated.

AB - Aims: To investigate the clinicopathological features of six unusual cases of nodal CD56+ and Epstein-Barr virus (EBV)+ T/natural killer (NK)-cell lymphoma, a putative nodal counterpart of nasal NK/T-cell lymphoma (nodal T/NK-cell lymphoma of nasal type) in comparison with nasal NK/T-cell lymphoma with secondary lymph node involvement (n = 24) and peripheral T-cell lymphoma (PTCL) of cytotoxic molecule (CTM)+ and EBV+ type (n = 21). Methods and results: All cases of nodal T/NK-cell lymphoma of nasal type exhibited diffuse infiltration of pleomorphic medium-sized to large tumour cells, reminiscent of those in CTM+ EBV+ PTCL. The tumour cells had a typical phenotype of nasal NK/T-cell lymphoma: CD2+, CD3ε+, CD4-, CD5-, CD56+, T-cell intracellular antigen-1+, granzyme B+, perforin+ and EBV+. However, four of six cases demonstrated clonal T-cell receptor γ-gene rearrangement on polymerase chain reaction analysis, unlike nasal NK/T-cell lymphoma. Comparison of clinical parameters and overall survival among the three groups demonstrated only minor differences. Conclusions: Nodal T/NK-cell lymphoma may occupy the grey zone between extranodal nasal-type NK/T-cell lymphoma and nodal CTM+ PTCL in a spectrum of NK to T-cell lymphomas that are EBV+. The close relationship between NK/T-cell lymphomas and cytotoxic T-cell lymphomas was also substantiated.

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KW - Nodal peripheral T-cell lymphoma

KW - TCRγ rearrangement

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