Nodal T/NK-cell lymphoma of nasal type: A clinicopathological study of six cases

E. Takahashi, N. Asano, C. Li, T. Tanaka, K. Shimada, S. Shimada, T. Yoshino, M. Kojima, K. Hara, T. Eimoto, S. Nakamura

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


Aims: To investigate the clinicopathological features of six unusual cases of nodal CD56+ and Epstein-Barr virus (EBV)+ T/natural killer (NK)-cell lymphoma, a putative nodal counterpart of nasal NK/T-cell lymphoma (nodal T/NK-cell lymphoma of nasal type) in comparison with nasal NK/T-cell lymphoma with secondary lymph node involvement (n = 24) and peripheral T-cell lymphoma (PTCL) of cytotoxic molecule (CTM)+ and EBV+ type (n = 21). Methods and results: All cases of nodal T/NK-cell lymphoma of nasal type exhibited diffuse infiltration of pleomorphic medium-sized to large tumour cells, reminiscent of those in CTM+ EBV+ PTCL. The tumour cells had a typical phenotype of nasal NK/T-cell lymphoma: CD2+, CD3ε+, CD4-, CD5-, CD56+, T-cell intracellular antigen-1+, granzyme B+, perforin+ and EBV+. However, four of six cases demonstrated clonal T-cell receptor γ-gene rearrangement on polymerase chain reaction analysis, unlike nasal NK/T-cell lymphoma. Comparison of clinical parameters and overall survival among the three groups demonstrated only minor differences. Conclusions: Nodal T/NK-cell lymphoma may occupy the grey zone between extranodal nasal-type NK/T-cell lymphoma and nodal CTM+ PTCL in a spectrum of NK to T-cell lymphomas that are EBV+. The close relationship between NK/T-cell lymphomas and cytotoxic T-cell lymphomas was also substantiated.

Original languageEnglish
Pages (from-to)585-596
Number of pages12
Issue number5
Publication statusPublished - Apr 2008


  • Cytotoxic phenotype
  • Epstein-Barr virus
  • NK/T-cell lymphoma
  • Nodal peripheral T-cell lymphoma
  • TCRγ rearrangement

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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