Nodal Peripheral T-cell Lymphoma with T Follicular Helper Phenotype Presenting as Chorea during Treatment: A Case Report and Literature Review

Wataru Kitamura, Daisuke Ennishi, Ryoya Yukawa, Ryo Sasaki, Chikamasa Yoshida, Hiroki Takasuka, Hideaki Fujiwara, Noboru Asada, Hisakazu Nishimori, Keiko Fujii, Nobuharu Fujii, Ken Ichi Matsuoka, Koji Abe, Tadashi Yoshino, Yoshinobu Maeda

Research output: Contribution to journalReview articlepeer-review

Abstract

A 72-year-old man presented with chorea while undergoing treatment for recurrence of nodal peripheral T-cell lymphoma with T follicular helper (TFH) phenotype. An examination by brain N-isopropyl-piodoamphetamine (123I-IMP)-single photon emission computed tomography (SPECT) revealed no abnormalities other than a decreased cerebral blood flow (CBF) in the left striatum. After four courses of salvage chemotherapy, his clinical symptoms and asymmetric cerebral perfusion improved, suggesting that the decreased CBF had caused chorea. The significance of brain SPECT has not been fully clarified in patients with chorea-associated malignant lymphoma, warranting further investigations. Brain SPECT is an alternative approach to identify abnormalities in such patients.

Original languageEnglish
Pages (from-to)3155-3160
Number of pages6
JournalInternal Medicine
Volume60
Issue number19
DOIs
Publication statusPublished - 2021
Externally publishedYes

Keywords

  • Chorea
  • Peripheral T-cell lymphoma
  • Single photon-emission computed tomography

ASJC Scopus subject areas

  • Internal Medicine

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