No significant association between HA-1 incompatibility and incidence of acute graft-versus-host disease after HLA-identical sibling bone marrow transplantation in Japanese patients

Makoto Murata, Nobuhiko Emi, Noriyuki Hirabayashi, Motohiro Hamaguchi, Seiichi Goto, Atushi Wakita, Mitsune Tanimoto, Hidehiko Saito, Yoshihisa Kodera, Yoshihisa Morishita

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We retrospectively examined HA-1 typing with polymerase chain reaction using sequence-specific primers in 120 samples from 60 HLA-A2-positive Japanese bone marrow transplantation recipients who received short-term methotrexate and cyclosporin A for graft-versus-host disease (GVHD) prophylaxis and their HLA-identical sibling donors. HA-1-incompatible pairs were observed in 22% of the samples. The probability of developing acute GVHD (grade II to IV) in HA-1-incompatible and -compatible patients was 0% and 19%, respectively (P = .10). In a comparison between HA-1-incompatible and -compatible patients with standard-risk leukemia, in whom age, patient/donor sex, and use of a total body irradiationcontaining regimen were equivalent, the probability of developing acute GVHD (grade II to IV) was 0% and 10%, respectively (P = .38). No evidence of recurrent leukemia was observed in the HA-1-incompatible patients with standard-risk leukemia, compared with 37% in HA-1-compatible patients (P = .11). In conclusion, HA-1 incompatibility may not be a risk factor for grade II to IV acute GVHD in Japanese patients who receive methotrexate and cyclosporin A and undergo bone marrow transplantation from HLA-identical sibling donors.

Original languageEnglish
Pages (from-to)371-375
Number of pages5
JournalInternational journal of hematology
Volume72
Issue number3
Publication statusPublished - 2000

Keywords

  • BMT
  • Graft-versus-host disease
  • Graft-versus-leukemia effect
  • HA-1
  • Minor histocompatibility antigen

ASJC Scopus subject areas

  • Hematology

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