No chromosomal clustering of housekeeping genes in the marine chordate Ciona intestinalis

Eiichi Shoguchi, Manabu Fujie, Mayuko Hamada

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Housekeeping genes, widely expressed genes that are required for the basal function of most cell types, are clustered in the human and worm genomes. This arrangement suggests coordinate control of housekeeping gene expression at the chromosomal level. Here we examined whether this notion is applicable to a marine chordate, Ciona intestinalis. Using microarrays, we analyzed genes that were expressed in 11 organs of the adult, including the neural complex, branchial sac, esophagus, stomach, endostyle, intestine, body-wall muscle, heart, blood cells, ovary and testis. This analysis identified 158 genes that are expressed ubiquitously in these organs. These housekeeping genes could be classified into a range of Gene Ontology categories, in particular, ribosomal protein components. Of these 158 genes, we were able to map 141 genes onto the 14 pairs of the C. intestinalis chromosomes. They were distributed rather evenly over all the chromosomes, except for small clusters containing two or three genes. Therefore, the notion of chromosomal clustering of housekeeping genes is not applicable in this chordate.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalMarine Genomics
Volume4
Issue number3
DOIs
Publication statusPublished - Sep 1 2011
Externally publishedYes

Keywords

  • Chromosomal distribution
  • Ciona intestinalis
  • Housekeeping genes
  • Microarray

ASJC Scopus subject areas

  • Aquatic Science
  • Genetics

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