No association between the sigma receptor type 1 gene and schizophrenia

Results of analysis and meta-analysis of case-control studies

Naohiko Uchida, Hiroshi Ujike, Kenji Nakata, Manabu Takaki, Akira Nomura, Takeshi Katsu, Yuji Tanaka, Takaki Imamura, Ayumu Sakai, Shigetoshi Kuroda

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Several lines of evidence have supported possible roles of the sigma receptors in the etiology of schizophrenia and mechanisms of antipsychotic efficacy. An association study provided genetic evidence that the sigma receptor type 1 gene (SIGMAR1) was a possible susceptibility factor for schizophrenia, however, it was not replicated by a subsequent study. It is necessary to evaluate further the possibility that the SIGMAR1 gene is associated with susceptibility to schizophrenia. Methods: A case-control association study between two polymorphisms of the SIGMAR1 gene, G-241T/C-240T and Gln2Pro, and schizophrenia in Japanese population, and meta-analysis including present and previous studies. Results: There was no significant association of any allele or genotype of the polymorphisms with schizophrenia. Neither significant association was observed with hebephrenic or paranoid subtype of schizophrenia. Furthermore, a meta-analysis including the present and previous studies comprising 779 controls and 636 schizophrenics also revealed no significant association between the SIGMAR1 gene and schizophrenia. Conclusion: In view of this evidence, it is likely that the SIGMAR1 gene does not confer susceptibility to schizophrenia.

Original languageEnglish
Article number13
JournalBMC Psychiatry
Volume3
DOIs
Publication statusPublished - Oct 21 2003

Fingerprint

Meta-Analysis
Case-Control Studies
Schizophrenia
Genes
sigma Receptors
Paranoid Schizophrenia
sigma-1 receptor
Genetic Association Studies
Antipsychotic Agents
Alleles
Genotype
Population

ASJC Scopus subject areas

  • Medicine(all)
  • Psychiatry and Mental health

Cite this

No association between the sigma receptor type 1 gene and schizophrenia : Results of analysis and meta-analysis of case-control studies. / Uchida, Naohiko; Ujike, Hiroshi; Nakata, Kenji; Takaki, Manabu; Nomura, Akira; Katsu, Takeshi; Tanaka, Yuji; Imamura, Takaki; Sakai, Ayumu; Kuroda, Shigetoshi.

In: BMC Psychiatry, Vol. 3, 13, 21.10.2003.

Research output: Contribution to journalArticle

Uchida, Naohiko ; Ujike, Hiroshi ; Nakata, Kenji ; Takaki, Manabu ; Nomura, Akira ; Katsu, Takeshi ; Tanaka, Yuji ; Imamura, Takaki ; Sakai, Ayumu ; Kuroda, Shigetoshi. / No association between the sigma receptor type 1 gene and schizophrenia : Results of analysis and meta-analysis of case-control studies. In: BMC Psychiatry. 2003 ; Vol. 3.
@article{884e8b547d0d45aeaf690bb8f52f7235,
title = "No association between the sigma receptor type 1 gene and schizophrenia: Results of analysis and meta-analysis of case-control studies",
abstract = "Background: Several lines of evidence have supported possible roles of the sigma receptors in the etiology of schizophrenia and mechanisms of antipsychotic efficacy. An association study provided genetic evidence that the sigma receptor type 1 gene (SIGMAR1) was a possible susceptibility factor for schizophrenia, however, it was not replicated by a subsequent study. It is necessary to evaluate further the possibility that the SIGMAR1 gene is associated with susceptibility to schizophrenia. Methods: A case-control association study between two polymorphisms of the SIGMAR1 gene, G-241T/C-240T and Gln2Pro, and schizophrenia in Japanese population, and meta-analysis including present and previous studies. Results: There was no significant association of any allele or genotype of the polymorphisms with schizophrenia. Neither significant association was observed with hebephrenic or paranoid subtype of schizophrenia. Furthermore, a meta-analysis including the present and previous studies comprising 779 controls and 636 schizophrenics also revealed no significant association between the SIGMAR1 gene and schizophrenia. Conclusion: In view of this evidence, it is likely that the SIGMAR1 gene does not confer susceptibility to schizophrenia.",
author = "Naohiko Uchida and Hiroshi Ujike and Kenji Nakata and Manabu Takaki and Akira Nomura and Takeshi Katsu and Yuji Tanaka and Takaki Imamura and Ayumu Sakai and Shigetoshi Kuroda",
year = "2003",
month = "10",
day = "21",
doi = "10.1186/1471-244X-3-13",
language = "English",
volume = "3",
journal = "BMC Psychiatry",
issn = "1471-244X",
publisher = "BioMed Central",

}

TY - JOUR

T1 - No association between the sigma receptor type 1 gene and schizophrenia

T2 - Results of analysis and meta-analysis of case-control studies

AU - Uchida, Naohiko

AU - Ujike, Hiroshi

AU - Nakata, Kenji

AU - Takaki, Manabu

AU - Nomura, Akira

AU - Katsu, Takeshi

AU - Tanaka, Yuji

AU - Imamura, Takaki

AU - Sakai, Ayumu

AU - Kuroda, Shigetoshi

PY - 2003/10/21

Y1 - 2003/10/21

N2 - Background: Several lines of evidence have supported possible roles of the sigma receptors in the etiology of schizophrenia and mechanisms of antipsychotic efficacy. An association study provided genetic evidence that the sigma receptor type 1 gene (SIGMAR1) was a possible susceptibility factor for schizophrenia, however, it was not replicated by a subsequent study. It is necessary to evaluate further the possibility that the SIGMAR1 gene is associated with susceptibility to schizophrenia. Methods: A case-control association study between two polymorphisms of the SIGMAR1 gene, G-241T/C-240T and Gln2Pro, and schizophrenia in Japanese population, and meta-analysis including present and previous studies. Results: There was no significant association of any allele or genotype of the polymorphisms with schizophrenia. Neither significant association was observed with hebephrenic or paranoid subtype of schizophrenia. Furthermore, a meta-analysis including the present and previous studies comprising 779 controls and 636 schizophrenics also revealed no significant association between the SIGMAR1 gene and schizophrenia. Conclusion: In view of this evidence, it is likely that the SIGMAR1 gene does not confer susceptibility to schizophrenia.

AB - Background: Several lines of evidence have supported possible roles of the sigma receptors in the etiology of schizophrenia and mechanisms of antipsychotic efficacy. An association study provided genetic evidence that the sigma receptor type 1 gene (SIGMAR1) was a possible susceptibility factor for schizophrenia, however, it was not replicated by a subsequent study. It is necessary to evaluate further the possibility that the SIGMAR1 gene is associated with susceptibility to schizophrenia. Methods: A case-control association study between two polymorphisms of the SIGMAR1 gene, G-241T/C-240T and Gln2Pro, and schizophrenia in Japanese population, and meta-analysis including present and previous studies. Results: There was no significant association of any allele or genotype of the polymorphisms with schizophrenia. Neither significant association was observed with hebephrenic or paranoid subtype of schizophrenia. Furthermore, a meta-analysis including the present and previous studies comprising 779 controls and 636 schizophrenics also revealed no significant association between the SIGMAR1 gene and schizophrenia. Conclusion: In view of this evidence, it is likely that the SIGMAR1 gene does not confer susceptibility to schizophrenia.

UR - http://www.scopus.com/inward/record.url?scp=2642570958&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2642570958&partnerID=8YFLogxK

U2 - 10.1186/1471-244X-3-13

DO - 10.1186/1471-244X-3-13

M3 - Article

VL - 3

JO - BMC Psychiatry

JF - BMC Psychiatry

SN - 1471-244X

M1 - 13

ER -