TY - JOUR
T1 - No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans
AU - Nakata, Kenji
AU - Ujike, Hiroshi
AU - Tanaka, Yuji
AU - Takaki, Manabu
AU - Sakai, Ayumu
AU - Nomura, Akira
AU - Katsu, Takeshi
AU - Uchida, Naohiko
AU - Imamura, Takaki
AU - Fujiwara, Yutaka
AU - Hamamura, Takashi
AU - Kuroda, Shigetoshi
PY - 2003/10/9
Y1 - 2003/10/9
N2 - Several susceptibility loci for both of schizophrenia and bipolar disorder (BPD) have been found to overlap on several chromosomes including 8p21. Expression of dihydropyrimidinase-related protein 2 (DRP-2), which gene is located on 8p21, was found to be reduced in the brains of individuals with schizophrenia and BPD. Recently, we demonstrated a significant association between the DRP-2 gene and schizophrenia. Based on the rationale, we investigated the genetic association of the DRP-2 gene with BPD using a case-control study in the Japanese population. However, no significant associations were found between five polymorphisms of the DRP-2 gene (-975C>G, 352G>A, 426C>T, 1506T>C, and *2236T>C), and BPD, nor were associations detected between either of the polymorphisms and any subtype of BPD, bipolars I and II. The present study did not provide any evidence for a contribution of the DRP-2 gene to susceptibility to BPD.
AB - Several susceptibility loci for both of schizophrenia and bipolar disorder (BPD) have been found to overlap on several chromosomes including 8p21. Expression of dihydropyrimidinase-related protein 2 (DRP-2), which gene is located on 8p21, was found to be reduced in the brains of individuals with schizophrenia and BPD. Recently, we demonstrated a significant association between the DRP-2 gene and schizophrenia. Based on the rationale, we investigated the genetic association of the DRP-2 gene with BPD using a case-control study in the Japanese population. However, no significant associations were found between five polymorphisms of the DRP-2 gene (-975C>G, 352G>A, 426C>T, 1506T>C, and *2236T>C), and BPD, nor were associations detected between either of the polymorphisms and any subtype of BPD, bipolars I and II. The present study did not provide any evidence for a contribution of the DRP-2 gene to susceptibility to BPD.
KW - Association study
KW - Bipolar disorder
KW - Collapsin response mediator protein 2
KW - Dihydropyrimidinase-related protein 2
KW - Polymorphism
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U2 - 10.1016/S0304-3940(03)00824-3
DO - 10.1016/S0304-3940(03)00824-3
M3 - Article
C2 - 12951196
AN - SCOPUS:0142091439
VL - 349
SP - 171
EP - 174
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -