No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans

Kenji Nakata, Hiroshi Ujike, Yuji Tanaka, Manabu Takaki, Ayumu Sakai, Akira Nomura, Takeshi Katsu, Naohiko Uchida, Takaki Imamura, Yutaka Fujiwara, Takashi Hamamura, Shigetoshi Kuroda

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9 Citations (Scopus)

Abstract

Several susceptibility loci for both of schizophrenia and bipolar disorder (BPD) have been found to overlap on several chromosomes including 8p21. Expression of dihydropyrimidinase-related protein 2 (DRP-2), which gene is located on 8p21, was found to be reduced in the brains of individuals with schizophrenia and BPD. Recently, we demonstrated a significant association between the DRP-2 gene and schizophrenia. Based on the rationale, we investigated the genetic association of the DRP-2 gene with BPD using a case-control study in the Japanese population. However, no significant associations were found between five polymorphisms of the DRP-2 gene (-975C>G, 352G>A, 426C>T, 1506T>C, and *2236T>C), and BPD, nor were associations detected between either of the polymorphisms and any subtype of BPD, bipolars I and II. The present study did not provide any evidence for a contribution of the DRP-2 gene to susceptibility to BPD.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalNeuroscience Letters
Volume349
Issue number3
DOIs
Publication statusPublished - Oct 9 2003

Keywords

  • Association study
  • Bipolar disorder
  • Collapsin response mediator protein 2
  • Dihydropyrimidinase-related protein 2
  • Polymorphism

ASJC Scopus subject areas

  • Neuroscience(all)

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    Nakata, K., Ujike, H., Tanaka, Y., Takaki, M., Sakai, A., Nomura, A., Katsu, T., Uchida, N., Imamura, T., Fujiwara, Y., Hamamura, T., & Kuroda, S. (2003). No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans. Neuroscience Letters, 349(3), 171-174. https://doi.org/10.1016/S0304-3940(03)00824-3