No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans

Kenji Nakata; Hiroshi Ujike; Yuji Tanaka; Manabu Takaki; Ayumu Sakai; Akira Nomura; Takeshi Katsu; Naohiko Uchida; Takaki Imamura; Yutaka Fujiwara; Takashi Hamamura; Shigetoshi Kuroda

doi:10.1016/S0304-3940(03)00824-3

No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans

Kenji Nakata, Hiroshi Ujike, Yuji Tanaka, Manabu Takaki, Ayumu Sakai, Akira Nomura, Takeshi Katsu, Naohiko Uchida, Takaki Imamura, Yutaka Fujiwara, Takashi Hamamura, Shigetoshi Kuroda

University Hospital

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Several susceptibility loci for both of schizophrenia and bipolar disorder (BPD) have been found to overlap on several chromosomes including 8p21. Expression of dihydropyrimidinase-related protein 2 (DRP-2), which gene is located on 8p21, was found to be reduced in the brains of individuals with schizophrenia and BPD. Recently, we demonstrated a significant association between the DRP-2 gene and schizophrenia. Based on the rationale, we investigated the genetic association of the DRP-2 gene with BPD using a case-control study in the Japanese population. However, no significant associations were found between five polymorphisms of the DRP-2 gene (-975C>G, 352G>A, 426C>T, 1506T>C, and *2236T>C), and BPD, nor were associations detected between either of the polymorphisms and any subtype of BPD, bipolars I and II. The present study did not provide any evidence for a contribution of the DRP-2 gene to susceptibility to BPD.

Original language	English
Pages (from-to)	171-174
Number of pages	4
Journal	Neuroscience Letters
Volume	349
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(03)00824-3
Publication status	Published - Oct 9 2003

Keywords

Association study
Bipolar disorder
Collapsin response mediator protein 2
Dihydropyrimidinase-related protein 2
Polymorphism

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(03)00824-3

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No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans. / Nakata, Kenji; Ujike, Hiroshi; Tanaka, Yuji; Takaki, Manabu; Sakai, Ayumu; Nomura, Akira; Katsu, Takeshi; Uchida, Naohiko; Imamura, Takaki; Fujiwara, Yutaka; Hamamura, Takashi; Kuroda, Shigetoshi.

In: Neuroscience Letters, Vol. 349, No. 3, 09.10.2003, p. 171-174.

Research output: Contribution to journal › Article › peer-review

Nakata, Kenji ; Ujike, Hiroshi ; Tanaka, Yuji ; Takaki, Manabu ; Sakai, Ayumu ; Nomura, Akira ; Katsu, Takeshi ; Uchida, Naohiko ; Imamura, Takaki ; Fujiwara, Yutaka ; Hamamura, Takashi ; Kuroda, Shigetoshi. / No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans. In: Neuroscience Letters. 2003 ; Vol. 349, No. 3. pp. 171-174.

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abstract = "Several susceptibility loci for both of schizophrenia and bipolar disorder (BPD) have been found to overlap on several chromosomes including 8p21. Expression of dihydropyrimidinase-related protein 2 (DRP-2), which gene is located on 8p21, was found to be reduced in the brains of individuals with schizophrenia and BPD. Recently, we demonstrated a significant association between the DRP-2 gene and schizophrenia. Based on the rationale, we investigated the genetic association of the DRP-2 gene with BPD using a case-control study in the Japanese population. However, no significant associations were found between five polymorphisms of the DRP-2 gene (-975C>G, 352G>A, 426C>T, 1506T>C, and *2236T>C), and BPD, nor were associations detected between either of the polymorphisms and any subtype of BPD, bipolars I and II. The present study did not provide any evidence for a contribution of the DRP-2 gene to susceptibility to BPD.",

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