Abstract
Nano-meter scale Ca-deficient hydroxyapatite (nano-apatite) is a potential candidate as artificial bone substitute materials owing to its similarity to the bone with respect to composition, morphology and osteoclastic degradation or adsorbent materials for blood purification therapy to remove pathogenic substances. The initial biodegradation behaviors, the initial cell-material interaction and the protein adsorption properties of nano-apatite must depend on the microstructure. The purpose of this study is the preparation of nano-apatite particles and their structural characterization by using X-ray diffraction (XRD) and solid-state NMR spectroscopy. The nano-apatite particles were prepared by precipitation processing method, and the effects of magnesium ions on the precipitation of calcium phosphate were examined, because Mg ions are well-known to play a role of inhibition of crystal growth. The addition of Mg ions led to the precipitation of nano-meter scale Ca-deficient apatite crystals having 1.33-1.63 of the molar ratio (Mg+Ca)/P. NMR analyses showed that the microstructure of Mg•HAp particles can be explained by a crystalline HAp core covered with a thin amorphous hydrated calcium phosphate layer.
| Original language | English |
|---|---|
| Title of host publication | Bioceramics 26 |
| Publisher | Trans Tech Publications Ltd |
| Pages | 57-60 |
| Number of pages | 4 |
| Volume | 631 |
| ISBN (Print) | 9783038352822 |
| DOIs | |
| Publication status | Published - 2015 |
| Event | 26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, ISCM 2014 - Barcelona, Spain Duration: Nov 6 2014 → Nov 8 2014 |
Publication series
| Name | Key Engineering Materials |
|---|---|
| Volume | 631 |
| ISSN (Print) | 10139826 |
Other
| Other | 26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, ISCM 2014 |
|---|---|
| Country | Spain |
| City | Barcelona |
| Period | 11/6/14 → 11/8/14 |
Fingerprint
Keywords
- Calcium Phosphate
- Disordered phase
- Nano-apatite
- NMR
- Structure
ASJC Scopus subject areas
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering
Cite this
NMR structural characterization of Mg-containing nano-apatite. / Hayakawa, Satoshi; Konishi, Toshiisa; Yoshioka, Tomohiko; Fujii, Eiji; Kawabata, Kouji.
Bioceramics 26. Vol. 631 Trans Tech Publications Ltd, 2015. p. 57-60 (Key Engineering Materials; Vol. 631).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - NMR structural characterization of Mg-containing nano-apatite
AU - Hayakawa, Satoshi
AU - Konishi, Toshiisa
AU - Yoshioka, Tomohiko
AU - Fujii, Eiji
AU - Kawabata, Kouji
PY - 2015
Y1 - 2015
N2 - Nano-meter scale Ca-deficient hydroxyapatite (nano-apatite) is a potential candidate as artificial bone substitute materials owing to its similarity to the bone with respect to composition, morphology and osteoclastic degradation or adsorbent materials for blood purification therapy to remove pathogenic substances. The initial biodegradation behaviors, the initial cell-material interaction and the protein adsorption properties of nano-apatite must depend on the microstructure. The purpose of this study is the preparation of nano-apatite particles and their structural characterization by using X-ray diffraction (XRD) and solid-state NMR spectroscopy. The nano-apatite particles were prepared by precipitation processing method, and the effects of magnesium ions on the precipitation of calcium phosphate were examined, because Mg ions are well-known to play a role of inhibition of crystal growth. The addition of Mg ions led to the precipitation of nano-meter scale Ca-deficient apatite crystals having 1.33-1.63 of the molar ratio (Mg+Ca)/P. NMR analyses showed that the microstructure of Mg•HAp particles can be explained by a crystalline HAp core covered with a thin amorphous hydrated calcium phosphate layer.
AB - Nano-meter scale Ca-deficient hydroxyapatite (nano-apatite) is a potential candidate as artificial bone substitute materials owing to its similarity to the bone with respect to composition, morphology and osteoclastic degradation or adsorbent materials for blood purification therapy to remove pathogenic substances. The initial biodegradation behaviors, the initial cell-material interaction and the protein adsorption properties of nano-apatite must depend on the microstructure. The purpose of this study is the preparation of nano-apatite particles and their structural characterization by using X-ray diffraction (XRD) and solid-state NMR spectroscopy. The nano-apatite particles were prepared by precipitation processing method, and the effects of magnesium ions on the precipitation of calcium phosphate were examined, because Mg ions are well-known to play a role of inhibition of crystal growth. The addition of Mg ions led to the precipitation of nano-meter scale Ca-deficient apatite crystals having 1.33-1.63 of the molar ratio (Mg+Ca)/P. NMR analyses showed that the microstructure of Mg•HAp particles can be explained by a crystalline HAp core covered with a thin amorphous hydrated calcium phosphate layer.
KW - Calcium Phosphate
KW - Disordered phase
KW - Nano-apatite
KW - NMR
KW - Structure
UR - http://www.scopus.com/inward/record.url?scp=84921793663&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84921793663&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net.KEM.631.57
DO - 10.4028/www.scientific.net.KEM.631.57
M3 - Conference contribution
AN - SCOPUS:84921793663
SN - 9783038352822
VL - 631
T3 - Key Engineering Materials
SP - 57
EP - 60
BT - Bioceramics 26
PB - Trans Tech Publications Ltd
ER -