TY - JOUR
T1 - NKX2-1/TTF-1
T2 - An Enigmatic Oncogene that Functions as a Double-Edged Sword for Cancer Cell Survival and Progression
AU - Yamaguchi, Tomoya
AU - Hosono, Yasuyuki
AU - Yanagisawa, Kiyoshi
AU - Takahashi, Takashi
N1 - Funding Information:
We thank all of the members of our research group for their invaluable contributions, including helpful discussions and critical comments. We also apologize for the incompleteness of the referencing due to space constraints. Studies in our laboratory have been supported in part by grants from the Ministry of Education, Science, Sports and Culture, Japan, and the Ministry of Health, Labor and Welfare, Japan.
PY - 2013/6/10
Y1 - 2013/6/10
N2 - Emerging evidence indicates that NKX2-1, a homeobox-containing transcription factor also known as TTF-1, plays a role as a "lineage-survival" oncogene in lung adenocarcinomas. In Tcell acute lymphoblastic leukemia, gene rearrangements lead to aberrant expression of NKX2-1/TTF-1. Despite accumulating evidence supporting its oncogenic role, it has become apparent that NKX2-1/TTF-1 expression also has biological and clinical functions in the opposite direction that act against tumor progression. Herein, we review recent findings showing these enigmatic double-edged characteristics, with special attention given to the roles of NKX2-1/TTF-1 in lung development and carcinogenesis.
AB - Emerging evidence indicates that NKX2-1, a homeobox-containing transcription factor also known as TTF-1, plays a role as a "lineage-survival" oncogene in lung adenocarcinomas. In Tcell acute lymphoblastic leukemia, gene rearrangements lead to aberrant expression of NKX2-1/TTF-1. Despite accumulating evidence supporting its oncogenic role, it has become apparent that NKX2-1/TTF-1 expression also has biological and clinical functions in the opposite direction that act against tumor progression. Herein, we review recent findings showing these enigmatic double-edged characteristics, with special attention given to the roles of NKX2-1/TTF-1 in lung development and carcinogenesis.
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U2 - 10.1016/j.ccr.2013.04.002
DO - 10.1016/j.ccr.2013.04.002
M3 - Review article
C2 - 23763999
AN - SCOPUS:84878965845
SN - 1535-6108
VL - 23
SP - 718
EP - 723
JO - Cancer Cell
JF - Cancer Cell
IS - 6
ER -
