NKX2-1/TTF-1: An Enigmatic Oncogene that Functions as a Double-Edged Sword for Cancer Cell Survival and Progression

Tomoya Yamaguchi, Yasuyuki Hosono, Kiyoshi Yanagisawa, Takashi Takahashi

Research output: Contribution to journalReview articlepeer-review

97 Citations (Scopus)

Abstract

Emerging evidence indicates that NKX2-1, a homeobox-containing transcription factor also known as TTF-1, plays a role as a "lineage-survival" oncogene in lung adenocarcinomas. In Tcell acute lymphoblastic leukemia, gene rearrangements lead to aberrant expression of NKX2-1/TTF-1. Despite accumulating evidence supporting its oncogenic role, it has become apparent that NKX2-1/TTF-1 expression also has biological and clinical functions in the opposite direction that act against tumor progression. Herein, we review recent findings showing these enigmatic double-edged characteristics, with special attention given to the roles of NKX2-1/TTF-1 in lung development and carcinogenesis.

Original languageEnglish
Pages (from-to)718-723
Number of pages6
JournalCancer Cell
Volume23
Issue number6
DOIs
Publication statusPublished - Jun 10 2013
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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