Nitrogen-containing verticillene diterpenoids from the Taiwanese soft coral Cespitularia taeniata

Ya Ching Shen, Yuan Bin Cheng, Jun'ichi Kobayashi, Takaaki Kubota, Yohei Takahashi, Yuzuru Mikami, Junji Ito, Yun Sheng Lin

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Extensive column chromatography of the ethanolic extract of the soft coral Cespitularia taeniata collected in Taiwan has resulted in the isolation of eight new nitrogen-containing verticillene diterpenes, designated cespitulactams D-K (1-8), together with three known diterpenes, cespitulactams A (9) and B (10) and cespitularin F. In addition, one new derivative, 6-O-acetylcespitulactam F (11), was prepared from compound 3. The structures of these compounds were elucidated on the basis of spectroscopic analyses, especially HRMS and 2D NMR experiments. The cytotoxicity against human oral epidermoid carcinoma (KB) and murine L1210 leukemia cell lines and antimicrobial activities of 1-8 and 11 were tested and evaluated. A biogenetic pathway for these novel diterpene alkaloids was also proposed.

Original languageEnglish
Pages (from-to)1961-1965
Number of pages5
JournalJournal of Natural Products
Volume70
Issue number12
DOIs
Publication statusPublished - Dec 2007
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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