Nitric oxide (NO) scavenging capacity of natural antioxidants

Yoshimi Sueishi, Masashi Hori, Masakazu Kita, Yashige Kotake

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


Nitric oxide (NO)-scavenging capacities of several hydrophilic antioxidants were determined by using the PTIO method, a competitive NO-scavenging method with 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO). Relative NO-scavenging rates of antioxidants were measured with respect to PTIO and the scavenging rate constants were calculated based on PTIO's rate constant. Results indicated that NO-scavenging rate constants of the antioxidants were: uric acid (2.5) > caffeic acid (1.2) > trolox (1.0) > genistein (0.19) > glutathione (0) ≈ N-acetylcysteine (0), where the numbers are expressed in trolox equivalent unit. The oxidation potentials of these antioxidants were measured and the order in the magnitude of oxidation potential was in good accordance with NO-scavenging capacity. Based on the results, we have suggested that the primary chemical process of the antioxidant reaction with NO can be characterised with the electron transfer from NO to the antioxidant.

Original languageEnglish
Pages (from-to)866-870
Number of pages5
JournalFood Chemistry
Issue number3
Publication statusPublished - Dec 1 2011


  • EPR
  • Hydrophilic antioxidants
  • Kinetic study
  • NO-scavenging capacity
  • Nitric oxide
  • PTIO

ASJC Scopus subject areas

  • Analytical Chemistry
  • Food Science


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