Nitric oxide (NO) scavenging capacity of natural antioxidants

Yoshimi Sueishi, Masashi Hori, Masakazu Kita, Yashige Kotake

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Nitric oxide (NO)-scavenging capacities of several hydrophilic antioxidants were determined by using the PTIO method, a competitive NO-scavenging method with 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO). Relative NO-scavenging rates of antioxidants were measured with respect to PTIO and the scavenging rate constants were calculated based on PTIO's rate constant. Results indicated that NO-scavenging rate constants of the antioxidants were: uric acid (2.5) > caffeic acid (1.2) > trolox (1.0) > genistein (0.19) > glutathione (0) ≈ N-acetylcysteine (0), where the numbers are expressed in trolox equivalent unit. The oxidation potentials of these antioxidants were measured and the order in the magnitude of oxidation potential was in good accordance with NO-scavenging capacity. Based on the results, we have suggested that the primary chemical process of the antioxidant reaction with NO can be characterised with the electron transfer from NO to the antioxidant.

Original languageEnglish
Pages (from-to)866-870
Number of pages5
JournalFood Chemistry
Volume129
Issue number3
DOIs
Publication statusPublished - Dec 1 2011

Fingerprint

Scavenging
nitric oxide
Nitric Oxide
Antioxidants
antioxidants
Rate constants
Chemical Phenomena
oxidation
Oxidation
acetylcysteine
Genistein
genistein
Acetylcysteine
uric acid
caffeic acid
Uric Acid
electron transfer
oxides
Glutathione
glutathione

Keywords

  • EPR
  • Hydrophilic antioxidants
  • Kinetic study
  • Nitric oxide
  • NO-scavenging capacity
  • PTIO

ASJC Scopus subject areas

  • Food Science
  • Analytical Chemistry

Cite this

Nitric oxide (NO) scavenging capacity of natural antioxidants. / Sueishi, Yoshimi; Hori, Masashi; Kita, Masakazu; Kotake, Yashige.

In: Food Chemistry, Vol. 129, No. 3, 01.12.2011, p. 866-870.

Research output: Contribution to journalArticle

Sueishi, Yoshimi ; Hori, Masashi ; Kita, Masakazu ; Kotake, Yashige. / Nitric oxide (NO) scavenging capacity of natural antioxidants. In: Food Chemistry. 2011 ; Vol. 129, No. 3. pp. 866-870.
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