Nitric oxide in septic and aseptic meningitis in children

H. Tsukahara, T. Haruta, I. Hata, M. Mayumi

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Abstract

To investigate the involvement of nitric oxide (NO) in childhood meningitis, we measured the concentrations of NO-2 (a stable metabolite of NO) in serial samples of cerebrospinal fluid (CSF) from 11 children with septic and 7 with aseptic meningitis and 26 control patients without meningitis. The mean concentration of NO-2 in samples obtained during the early stages of septic meningitis, but not aseptic meningitis, was significantly higher than in control samples. Clinical and laboratory improvement following administration of antibiotics and dexamethasone was associated with a fall in CSF [NO-2] to normal levels in these patients. CSF [NO-2] remained almost consistently within the normal range in patients with aseptic meningitis. Our findings indicate that NO production is enhanced in the CSF compartment of children with septic meningitis and support the hypothesis that NO is involved in the pathophysiology of septic meningitis.

Original languageEnglish
Pages (from-to)73-80
Number of pages8
JournalScandinavian Journal of Clinical and Laboratory Investigation
Volume58
Issue number1
DOIs
Publication statusPublished - Jan 1 1998
Externally publishedYes

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Keywords

  • Cerebrospinal fluid
  • Cytokine
  • Lipopolysaccharide
  • NO

ASJC Scopus subject areas

  • Clinical Biochemistry

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