Nicotinic acetylcholine receptor density in cognitively intact subjects at an early stage of Parkinson's disease

Ioannis Ugo Isaias, Jörg Spiegel, Joachim Brumberg, Kelly P. Cosgrove, Giorgio Marotta, Naoya Oishi, Takahiro Higuchi, Sebastian Küsters, Markus Schiller, Ulrich Dillmann, Christopher H. van Dyck, Andreas Buck, Ken Herrmann, Susanne Schloegl, Jens Volkmann, Michael Lassmann, Klaus Fassbender, Reinhard Lorenz, Samuel Samnick

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

We investigated in vivo brain nicotinic acetylcholine receptor (nAChR) distribution in cognitively intact subjects with Parkinson's disease (PD) at an early stage of the disease. Fourteen patients and 13 healthy subjects were imaged with single photon emission computed tomography and the radiotracer 5-[123I]iodo-3-[2(S)-2-azetidinylmethoxy]pyridine ([123I]5IA). Patients were selected according to several criteria, including short duration of motor signs (<7 years) and normal scores at an extensive neuropsychological evaluation. In PD patients, nAChR density was significantly higher in the putamen, the insular cortex and the supplementary motor area and lower in the caudate nucleus, the orbitofrontal cortex, and the middle temporal gyrus. Disease duration positively correlated with nAChR density in the putamen ipsilateral (ρ = 0.56, p < 0.05) but not contralateral (ρ = 0.49, p = 0.07) to the clinically most affected hemibody. We observed, for the first time in vivo, higher nAChR density in brain regions of the motor and limbic basal ganglia circuits of subjects with PD. Our findings support the notion of an up-regulated cholinergic activity at the striatal and possibly cortical level in cognitively intact PD patients at an early stage of disease.

Original languageEnglish
Article numberArticle 213
JournalFrontiers in Aging Neuroscience
Volume6
Issue numberAUG
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • 5IA-SPECT
  • Cognitive decline
  • Dopamine acetylcholine
  • Nicotinic receptors
  • Parkinson disease

ASJC Scopus subject areas

  • Ageing
  • Cognitive Neuroscience

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