TY - JOUR
T1 - Nicotinic acetylcholine α4β2 receptor regulates the motivational effect of intracranial self stimulation behavior in the runway method
AU - Sagara, Hidenori
AU - Kitamura, Yoshihisa
AU - Yae, Tetsuji
AU - Shibata, Kazuhiko
AU - Suemaru, Katsuya
AU - Sendo, Toshiaki
AU - Araki, Hiroaki
AU - Gomita, Yutaka
PY - 2008
Y1 - 2008
N2 - Recently, it was demonstrated that the priming stimulation effect (PSE) of intracranial self-stimulation (ICSS) with the runway method can be used as a model system to study the motivation that contributes to specific behaviors. It was postulated that these behaviors could be used to compare the effects of various drugs on the mechanism of motivation. In the present study, the influences of nicotine, methyllycaconitine (α7 nicotine-receptor antagonist), and dihydro-β-erythroidine (α4β2 nicotine-receptor antagonist) on motivation were examined using the runway method for ICSS. Electrodes were implanted into the medial forebrain bundle of Wistar rats. The rats ran to the goal lever to get the reward (50 - 200 μA, 0.2 ms, 60 Hz) and pretrial electric stimulation (priming stimulation) in the medial forebrain bundle was performed. The experiment measured the running time from the start box until the rat pressed the goal lever for the reward stimulation. Under these reward and priming stimulation conditions, nicotine (0.2 mg/kg) induced a significant increase in running speed. The nicotine receptor antagonist α4β2 rather than α7 showed a dose-dependent antagonistic action on the effect of nicotine on running speed. These results demonstrate that nicotine enhances the running speed towards the goal lever via α4β2 nicotinic receptors and suggest that α4β2 nicotinic receptors influence the brain mechanism of motivation.
AB - Recently, it was demonstrated that the priming stimulation effect (PSE) of intracranial self-stimulation (ICSS) with the runway method can be used as a model system to study the motivation that contributes to specific behaviors. It was postulated that these behaviors could be used to compare the effects of various drugs on the mechanism of motivation. In the present study, the influences of nicotine, methyllycaconitine (α7 nicotine-receptor antagonist), and dihydro-β-erythroidine (α4β2 nicotine-receptor antagonist) on motivation were examined using the runway method for ICSS. Electrodes were implanted into the medial forebrain bundle of Wistar rats. The rats ran to the goal lever to get the reward (50 - 200 μA, 0.2 ms, 60 Hz) and pretrial electric stimulation (priming stimulation) in the medial forebrain bundle was performed. The experiment measured the running time from the start box until the rat pressed the goal lever for the reward stimulation. Under these reward and priming stimulation conditions, nicotine (0.2 mg/kg) induced a significant increase in running speed. The nicotine receptor antagonist α4β2 rather than α7 showed a dose-dependent antagonistic action on the effect of nicotine on running speed. These results demonstrate that nicotine enhances the running speed towards the goal lever via α4β2 nicotinic receptors and suggest that α4β2 nicotinic receptors influence the brain mechanism of motivation.
KW - Dihydro-β-erythroidine
KW - Intracranial self-stimulation
KW - Methyllycaconitine
KW - Motivation
KW - Nicotine
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U2 - 10.1254/jphs.08168FP
DO - 10.1254/jphs.08168FP
M3 - Article
C2 - 19057129
AN - SCOPUS:58149154837
VL - 108
SP - 455
EP - 461
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
SN - 1347-8648
IS - 4
ER -