Nicotinamide-N-methyltransferase is higher in the lumbar cerebrospinal fluid of patients with Parkinson's disease

Koji Aoyama, Kazuo Matsubara, Masahiro Kondo, Yohko Murakawa, Manabu Suno, Kazuya Yamashita, Shuhei Yamaguchi, Shotai Kobayashi

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Abstract

Parkinson's disease (PD) may be initiated or precipitated by endogenous toxins with a structure similar to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in genetically-predisposed individuals. Nicotinamide N-methyltransferase (NNMT) catalyzes N-methylation of nicotinamide and other pyridines to form pyridinium ions. The protein amount of NNMT was measured in the lumbar cerebrospinal fluid of PD patients by immunoblot analysis using anti-human NNMT antibody. In younger (65 years old or younger) PD patients, the relative level of NNMT protein was significantly higher than that in younger controls. The NNMT protein was significantly affected by aging: the amount decreased along with aging in PD patients. These findings suggested that excess NNMT in the central nervous system might be implicated in the PD pathogenesis.

Original languageEnglish
Pages (from-to)78-80
Number of pages3
JournalNeuroscience Letters
Volume298
Issue number1
DOIs
Publication statusPublished - Jan 26 2001

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Keywords

  • Aging
  • Azaheterocyclic amines
  • Cerebrospinal fluid
  • N-Methylation
  • Neurotoxicity
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)

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