Nickel-Catalyzed Decarbonylative Reductive Alkylation of Aroyl Fluorides with Alkyl Bromides

Qiang Chen; Jingwen You; Tian Tian; Zhenyao Li; Myuto Kashihara; Hiroki Mori; Yasushi Nishihara

doi:10.1021/acs.orglett.2c03823

Nickel-Catalyzed Decarbonylative Reductive Alkylation of Aroyl Fluorides with Alkyl Bromides

Qiang Chen, Jingwen You, Tian Tian, Zhenyao Li, Myuto Kashihara, Hiroki Mori, Yasushi Nishihara

Research output: Contribution to journal › Article › peer-review

Abstract

This paper describes the nickel-catalyzed reductive alkylation of aroyl fluorides with alkyl bromides in a decarbonylative manner. In this reaction, various functional groups are well tolerated and the C(sp2)-C(sp3) bond can be constructed directly without the use of organometallic reagents. The present reaction is a cross-electrophile coupling via the radical pathway, affording the corresponding alkylarenes in moderate to good yields.

Original language	English
Pages (from-to)	9259-9263
Number of pages	5
Journal	Organic Letters
Volume	24
Issue number	50
DOIs	https://doi.org/10.1021/acs.orglett.2c03823
Publication status	Published - Dec 23 2022

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.2c03823

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title = "Nickel-Catalyzed Decarbonylative Reductive Alkylation of Aroyl Fluorides with Alkyl Bromides",

abstract = "This paper describes the nickel-catalyzed reductive alkylation of aroyl fluorides with alkyl bromides in a decarbonylative manner. In this reaction, various functional groups are well tolerated and the C(sp2)-C(sp3) bond can be constructed directly without the use of organometallic reagents. The present reaction is a cross-electrophile coupling via the radical pathway, affording the corresponding alkylarenes in moderate to good yields.",

author = "Qiang Chen and Jingwen You and Tian Tian and Zhenyao Li and Myuto Kashihara and Hiroki Mori and Yasushi Nishihara",

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T1 - Nickel-Catalyzed Decarbonylative Reductive Alkylation of Aroyl Fluorides with Alkyl Bromides

AU - Chen, Qiang

AU - You, Jingwen

AU - Tian, Tian

AU - Li, Zhenyao

AU - Kashihara, Myuto

AU - Mori, Hiroki

AU - Nishihara, Yasushi

PY - 2022/12/23

Y1 - 2022/12/23

N2 - This paper describes the nickel-catalyzed reductive alkylation of aroyl fluorides with alkyl bromides in a decarbonylative manner. In this reaction, various functional groups are well tolerated and the C(sp2)-C(sp3) bond can be constructed directly without the use of organometallic reagents. The present reaction is a cross-electrophile coupling via the radical pathway, affording the corresponding alkylarenes in moderate to good yields.

AB - This paper describes the nickel-catalyzed reductive alkylation of aroyl fluorides with alkyl bromides in a decarbonylative manner. In this reaction, various functional groups are well tolerated and the C(sp2)-C(sp3) bond can be constructed directly without the use of organometallic reagents. The present reaction is a cross-electrophile coupling via the radical pathway, affording the corresponding alkylarenes in moderate to good yields.

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JO - Organic Letters

JF - Organic Letters

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ER -

Nickel-Catalyzed Decarbonylative Reductive Alkylation of Aroyl Fluorides with Alkyl Bromides

Abstract

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