Nickel-Catalyzed Decarbonylative Cyanation of Acyl Chlorides

Zhenhua Wang, Xiu Wang, Yasuyuki Ura, Yasushi Nishihara

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)


    Ni-catalyzed decarbonylative cyanation of acyl chlorides with trimethylsilyl cyanide has been achieved. This transformation is applicable to the synthesis of an array of nitrile compounds bearing a wide range of functional groups under neutral conditions. The step-by-step experimental studies revealed that the reaction sequences of the present catalytic reaction are oxidative addition, transmetalation, decarbonylation, and reductive elimination.

    Original languageEnglish
    Pages (from-to)6779-6784
    Number of pages6
    JournalOrganic Letters
    Issue number17
    Publication statusPublished - Sep 6 2019

    ASJC Scopus subject areas

    • Biochemistry
    • Physical and Theoretical Chemistry
    • Organic Chemistry


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