Nickel-Catalyzed Decarbonylative Cyanation of Acyl Chlorides

Zhenhua Wang, Xiu Wang, Yasuyuki Ura, Yasushi Nishihara

Research output: Contribution to journalArticle

Abstract

Ni-catalyzed decarbonylative cyanation of acyl chlorides with trimethylsilyl cyanide has been achieved. This transformation is applicable to the synthesis of an array of nitrile compounds bearing a wide range of functional groups under neutral conditions. The step-by-step experimental studies revealed that the reaction sequences of the present catalytic reaction are oxidative addition, transmetalation, decarbonylation, and reductive elimination.

Original languageEnglish
JournalOrganic Letters
DOIs
Publication statusAccepted/In press - Jan 1 2019

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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