Abstract
Ni-catalyzed decarbonylative cyanation of acyl chlorides with trimethylsilyl cyanide has been achieved. This transformation is applicable to the synthesis of an array of nitrile compounds bearing a wide range of functional groups under neutral conditions. The step-by-step experimental studies revealed that the reaction sequences of the present catalytic reaction are oxidative addition, transmetalation, decarbonylation, and reductive elimination.
| Original language | English |
|---|---|
| Pages (from-to) | 6779-6784 |
| Number of pages | 6 |
| Journal | Organic Letters |
| Volume | 21 |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - Sept 6 2019 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry