Nickel-Catalyzed Decarbonylative Cyanation of Acyl Chlorides

Zhenhua Wang, Xiu Wang, Yasuyuki Ura, Yasushi Nishihara

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Ni-catalyzed decarbonylative cyanation of acyl chlorides with trimethylsilyl cyanide has been achieved. This transformation is applicable to the synthesis of an array of nitrile compounds bearing a wide range of functional groups under neutral conditions. The step-by-step experimental studies revealed that the reaction sequences of the present catalytic reaction are oxidative addition, transmetalation, decarbonylation, and reductive elimination.

Original languageEnglish
Pages (from-to)6779-6784
Number of pages6
JournalOrganic Letters
Issue number17
Publication statusPublished - Sept 6 2019

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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