Nickel-Catalyzed Decarbonylative Alkynylation of Acyl Fluorides with Terminal Alkynes under Copper-Free Conditions

Qiang Chen, Liyan Fu, Jingwen You, Yasushi Nishihara

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Nickel-catalyzed decarbonylative alkynylation of acyl fluorides with terminal silylethynes under copper-free conditions is described. This newly developed method has a wide substrate scope, affording internal silylethynes in moderate to high yields. The formation of 1,3-diynes as homocoupled products and conjugate enones as carbonyl-retentive products were effectively suppressed.

Original languageEnglish
Article numberst-2020-k0490-c
Pages (from-to)1560-1564
Number of pages5
JournalSynlett
Volume32
Issue number15
DOIs
Publication statusPublished - Sep 16 2021

Keywords

  • acyl fluorides
  • alkynylation
  • decarbonylation
  • nickel catalysis
  • sila-Sonogashira-Hagihara reaction
  • silylalkynes

ASJC Scopus subject areas

  • Organic Chemistry

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