Nickel-catalyzed decarbonylative alkynylation of acyl fluorides with terminal silylethynes under copper-free conditions is described. This newly developed method has a wide substrate scope, affording internal silylethynes in moderate to high yields. The formation of 1,3-diynes as homocoupled products and conjugate enones as carbonyl-retentive products were effectively suppressed.
- acyl fluorides
- nickel catalysis
- sila-Sonogashira-Hagihara reaction
ASJC Scopus subject areas
- Organic Chemistry