Nickel-catalyzed [2 + 2 + 2] cycloaddition reaction of isocyanates with 1,3-dienes

Masao Morimoto, Yui Nishida, Tomoya Miura, Masahiro Murakami

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Two molecules of an isocyanate react with one molecule of a 1,3-diene in the presence of a nickel(0) catalyst to give a 6-substituted dihydropyrimidine-2,4-dione. A five-membered azanickelacyclic intermediate is initially generated through oxidative cyclization of a hetero-pair of the isocyanate and the 1,3-diene onto nickel(0). Another molecule of the isocyanate is subsequently incorporated therein and reductive elimination follows.

Original languageEnglish
Pages (from-to)550-552
Number of pages3
JournalChemistry Letters
Volume42
Issue number5
DOIs
Publication statusPublished - 2013
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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