Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis

Rie Kinoshita, Hiroki Sato, Akira Yamauchi, Yuta Takahashi, Yusuke Inoue, I. Wayan Sumardika, Youyi Chen, Nahoko Tomonobu, Kota Araki, Kazuhiko Shien, Shuta Tomida, Hidejiro Torigoe, Kei Namba, Eisuke Kurihara, Yusuke Ogoshi, Hitoshi Murata, Ken-ichi Yamamoto, Junichiro Futami, Endy Widya Putranto, I. Made Winarsa Ruma & 7 others Hiromasa Yamamoto, Junichi Sou, Toshihiko Hibino, Masahiro Nishibori, Eisaku Kondo, Shinichi Toyooka, Masakiyo Sakaguchi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The metastatic dissemination of cancer cells to remote areas of the body is the most problematic aspect in cancer patients. Among cancers, melanomas are notoriously difficult to treat due to their significantly high metastatic potential even during early stages. Hence, the establishment of advanced therapeutic approaches to regulate metastasis is required to overcome the melanoma disease. An accumulating mass of evidence has indicated a critical role of extracellular S100A8/A9 in melanoma distant metastasis. Lung S100A8/A9 is induced by melanoma cells from distant organs and it attracts these cells to its enriched lung environment since melanoma cells possess several receptors that sense the S100A8/A9 ligand. We hence aimed to develop a neutralizing antibody against S100A8/A9 that would efficiently block melanoma lung metastasis. Our protocol provided us with one prominent antibody, Ab45 that efficiently suppressed not only S100A8/A9-mediated melanoma mobility but also lung tropic melanoma metastasis in a mouse model. This prompted us to make chimeric Ab45, a chimera antibody consisting of mouse Ab45-Fab and human IgG2-Fc. Chimeric Ab45 also showed significant inhibition of the lung metastasis of melanoma. From these results, we have high hopes that the newly produced antibody will become a potential biological tool to block melanoma metastasis in future clinical settings.

Original languageEnglish
JournalInternational Journal of Cancer
DOIs
Publication statusAccepted/In press - Jan 1 2018

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Melanoma
Lung Neoplasms
Monoclonal Antibodies
Neoplasm Metastasis
Lung
Antibodies
Neoplasms
Neutralizing Antibodies
Immunoglobulin G
Ligands

Keywords

  • antibody
  • metastasis
  • S100A8/A9

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis. / Kinoshita, Rie; Sato, Hiroki; Yamauchi, Akira; Takahashi, Yuta; Inoue, Yusuke; Sumardika, I. Wayan; Chen, Youyi; Tomonobu, Nahoko; Araki, Kota; Shien, Kazuhiko; Tomida, Shuta; Torigoe, Hidejiro; Namba, Kei; Kurihara, Eisuke; Ogoshi, Yusuke; Murata, Hitoshi; Yamamoto, Ken-ichi; Futami, Junichiro; Putranto, Endy Widya; Ruma, I. Made Winarsa; Yamamoto, Hiromasa; Sou, Junichi; Hibino, Toshihiko; Nishibori, Masahiro; Kondo, Eisaku; Toyooka, Shinichi; Sakaguchi, Masakiyo.

In: International Journal of Cancer, 01.01.2018.

Research output: Contribution to journalArticle

Kinoshita, R, Sato, H, Yamauchi, A, Takahashi, Y, Inoue, Y, Sumardika, IW, Chen, Y, Tomonobu, N, Araki, K, Shien, K, Tomida, S, Torigoe, H, Namba, K, Kurihara, E, Ogoshi, Y, Murata, H, Yamamoto, K, Futami, J, Putranto, EW, Ruma, IMW, Yamamoto, H, Sou, J, Hibino, T, Nishibori, M, Kondo, E, Toyooka, S & Sakaguchi, M 2018, 'Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis', International Journal of Cancer. https://doi.org/10.1002/ijc.31982
Kinoshita, Rie ; Sato, Hiroki ; Yamauchi, Akira ; Takahashi, Yuta ; Inoue, Yusuke ; Sumardika, I. Wayan ; Chen, Youyi ; Tomonobu, Nahoko ; Araki, Kota ; Shien, Kazuhiko ; Tomida, Shuta ; Torigoe, Hidejiro ; Namba, Kei ; Kurihara, Eisuke ; Ogoshi, Yusuke ; Murata, Hitoshi ; Yamamoto, Ken-ichi ; Futami, Junichiro ; Putranto, Endy Widya ; Ruma, I. Made Winarsa ; Yamamoto, Hiromasa ; Sou, Junichi ; Hibino, Toshihiko ; Nishibori, Masahiro ; Kondo, Eisaku ; Toyooka, Shinichi ; Sakaguchi, Masakiyo. / Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis. In: International Journal of Cancer. 2018.
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AU - Takahashi, Yuta

AU - Inoue, Yusuke

AU - Sumardika, I. Wayan

AU - Chen, Youyi

AU - Tomonobu, Nahoko

AU - Araki, Kota

AU - Shien, Kazuhiko

AU - Tomida, Shuta

AU - Torigoe, Hidejiro

AU - Namba, Kei

AU - Kurihara, Eisuke

AU - Ogoshi, Yusuke

AU - Murata, Hitoshi

AU - Yamamoto, Ken-ichi

AU - Futami, Junichiro

AU - Putranto, Endy Widya

AU - Ruma, I. Made Winarsa

AU - Yamamoto, Hiromasa

AU - Sou, Junichi

AU - Hibino, Toshihiko

AU - Nishibori, Masahiro

AU - Kondo, Eisaku

AU - Toyooka, Shinichi

AU - Sakaguchi, Masakiyo

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