Abstract
Background. Many patients with fulminant hepatic failure die before receiving liver transplantation because of the difficulty of pinpointing the suitable timing for liver transplantation. The revised King's College criteria are useful for patients with acetaminophen-related fulminant hepatic failure; however, in those with non-acetaminophen-related fulminant hepatic failure, a new prognostic system that can accurately identify the suitable timing for liver transplantation is required. Methods. Using the first sample consisted of eighty patients with fulminant hepatic failure, we examined 2-week poor prognostic parameters at the time of diagnosis of fulminant hepatic failure (day 1) and on days 4, 8, and 15, respectively, and a 2-week prognostic scoring model was constructed. To confirm the accuracy of this model, validation was performed in the second sample consisting of 26 patients. Results. Cause of fulminant hepatic failure (hepatitis B virus or indeterminate), hepatic coma grade (III or IV), systemic inflammatory response syndrome (yes) and ratio of total to direct bilirubin (> 2.0) were associated with 2-week outcomes during days 1-15. Each of these four parameters was valued at +1. The 2-week survival rate in patients scoring
| Original language | English |
|---|---|
| Pages (from-to) | 930-936 |
| Number of pages | 7 |
| Journal | Transplantation |
| Volume | 80 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Oct 15 2005 |
Fingerprint
Keywords
- Fulminant hepatic failure
- Prognostic scoring model
- Systemic inflammatory response syndrome
ASJC Scopus subject areas
- Transplantation
- Immunology
Cite this
New prognostic scoring model for liver transplantation in patients with non-acetaminophen-related fulminant hepatic failure. / Miyake, Yasuhiro; Sakaguchi, Kohsaku; Iwasaki, Yoshiaki; Ikeda, Hiroshi; Makino, Yasuhiro; Kobashi, Haruhiko; Araki, Yasuyuki; Ando, Masaharu; Kita, Keiji; Shiratori, Yasushi.
In: Transplantation, Vol. 80, No. 7, 15.10.2005, p. 930-936.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New prognostic scoring model for liver transplantation in patients with non-acetaminophen-related fulminant hepatic failure
AU - Miyake, Yasuhiro
AU - Sakaguchi, Kohsaku
AU - Iwasaki, Yoshiaki
AU - Ikeda, Hiroshi
AU - Makino, Yasuhiro
AU - Kobashi, Haruhiko
AU - Araki, Yasuyuki
AU - Ando, Masaharu
AU - Kita, Keiji
AU - Shiratori, Yasushi
PY - 2005/10/15
Y1 - 2005/10/15
N2 - Background. Many patients with fulminant hepatic failure die before receiving liver transplantation because of the difficulty of pinpointing the suitable timing for liver transplantation. The revised King's College criteria are useful for patients with acetaminophen-related fulminant hepatic failure; however, in those with non-acetaminophen-related fulminant hepatic failure, a new prognostic system that can accurately identify the suitable timing for liver transplantation is required. Methods. Using the first sample consisted of eighty patients with fulminant hepatic failure, we examined 2-week poor prognostic parameters at the time of diagnosis of fulminant hepatic failure (day 1) and on days 4, 8, and 15, respectively, and a 2-week prognostic scoring model was constructed. To confirm the accuracy of this model, validation was performed in the second sample consisting of 26 patients. Results. Cause of fulminant hepatic failure (hepatitis B virus or indeterminate), hepatic coma grade (III or IV), systemic inflammatory response syndrome (yes) and ratio of total to direct bilirubin (> 2.0) were associated with 2-week outcomes during days 1-15. Each of these four parameters was valued at +1. The 2-week survival rate in patients scoring
AB - Background. Many patients with fulminant hepatic failure die before receiving liver transplantation because of the difficulty of pinpointing the suitable timing for liver transplantation. The revised King's College criteria are useful for patients with acetaminophen-related fulminant hepatic failure; however, in those with non-acetaminophen-related fulminant hepatic failure, a new prognostic system that can accurately identify the suitable timing for liver transplantation is required. Methods. Using the first sample consisted of eighty patients with fulminant hepatic failure, we examined 2-week poor prognostic parameters at the time of diagnosis of fulminant hepatic failure (day 1) and on days 4, 8, and 15, respectively, and a 2-week prognostic scoring model was constructed. To confirm the accuracy of this model, validation was performed in the second sample consisting of 26 patients. Results. Cause of fulminant hepatic failure (hepatitis B virus or indeterminate), hepatic coma grade (III or IV), systemic inflammatory response syndrome (yes) and ratio of total to direct bilirubin (> 2.0) were associated with 2-week outcomes during days 1-15. Each of these four parameters was valued at +1. The 2-week survival rate in patients scoring
KW - Fulminant hepatic failure
KW - Prognostic scoring model
KW - Systemic inflammatory response syndrome
UR - http://www.scopus.com/inward/record.url?scp=27644539244&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27644539244&partnerID=8YFLogxK
U2 - 10.1097/01.tp.0000173651.39645.35
DO - 10.1097/01.tp.0000173651.39645.35
M3 - Article
C2 - 16249741
AN - SCOPUS:27644539244
VL - 80
SP - 930
EP - 936
JO - Transplantation
JF - Transplantation
SN - 0041-1337
IS - 7
ER -