New prognostic scoring model for liver transplantation in patients with non-acetaminophen-related fulminant hepatic failure

Yasuhiro Miyake, Kohsaku Sakaguchi, Yoshiaki Iwasaki, Hiroshi Ikeda, Yasuhiro Makino, Haruhiko Kobashi, Yasuyuki Araki, Masaharu Ando, Keiji Kita, Yasushi Shiratori

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background. Many patients with fulminant hepatic failure die before receiving liver transplantation because of the difficulty of pinpointing the suitable timing for liver transplantation. The revised King's College criteria are useful for patients with acetaminophen-related fulminant hepatic failure; however, in those with non-acetaminophen-related fulminant hepatic failure, a new prognostic system that can accurately identify the suitable timing for liver transplantation is required. Methods. Using the first sample consisted of eighty patients with fulminant hepatic failure, we examined 2-week poor prognostic parameters at the time of diagnosis of fulminant hepatic failure (day 1) and on days 4, 8, and 15, respectively, and a 2-week prognostic scoring model was constructed. To confirm the accuracy of this model, validation was performed in the second sample consisting of 26 patients. Results. Cause of fulminant hepatic failure (hepatitis B virus or indeterminate), hepatic coma grade (III or IV), systemic inflammatory response syndrome (yes) and ratio of total to direct bilirubin (> 2.0) were associated with 2-week outcomes during days 1-15. Each of these four parameters was valued at +1. The 2-week survival rate in patients scoring

Original languageEnglish
Pages (from-to)930-936
Number of pages7
JournalTransplantation
Volume80
Issue number7
DOIs
Publication statusPublished - Oct 15 2005

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Acute Liver Failure
Liver Transplantation
Systemic Inflammatory Response Syndrome
Hepatic Encephalopathy
Acetaminophen
Bilirubin
Hepatitis B virus
Survival Rate

Keywords

  • Fulminant hepatic failure
  • Prognostic scoring model
  • Systemic inflammatory response syndrome

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

New prognostic scoring model for liver transplantation in patients with non-acetaminophen-related fulminant hepatic failure. / Miyake, Yasuhiro; Sakaguchi, Kohsaku; Iwasaki, Yoshiaki; Ikeda, Hiroshi; Makino, Yasuhiro; Kobashi, Haruhiko; Araki, Yasuyuki; Ando, Masaharu; Kita, Keiji; Shiratori, Yasushi.

In: Transplantation, Vol. 80, No. 7, 15.10.2005, p. 930-936.

Research output: Contribution to journalArticle

Miyake, Y, Sakaguchi, K, Iwasaki, Y, Ikeda, H, Makino, Y, Kobashi, H, Araki, Y, Ando, M, Kita, K & Shiratori, Y 2005, 'New prognostic scoring model for liver transplantation in patients with non-acetaminophen-related fulminant hepatic failure', Transplantation, vol. 80, no. 7, pp. 930-936. https://doi.org/10.1097/01.tp.0000173651.39645.35
Miyake, Yasuhiro ; Sakaguchi, Kohsaku ; Iwasaki, Yoshiaki ; Ikeda, Hiroshi ; Makino, Yasuhiro ; Kobashi, Haruhiko ; Araki, Yasuyuki ; Ando, Masaharu ; Kita, Keiji ; Shiratori, Yasushi. / New prognostic scoring model for liver transplantation in patients with non-acetaminophen-related fulminant hepatic failure. In: Transplantation. 2005 ; Vol. 80, No. 7. pp. 930-936.
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