New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities

Hien Minh Nguyen, Takuya Ito, Shin ichiro Kurimoto, Mika Ogawa, Nwet Nwet Win, Vo Quoc Hung, Hoai Thi Nguyen, Takaaki Kubota, Jun'ichi Kobayashi, Hiroyuki Morita

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The investigation of the Vietnamese marine sponge Spongia sp. led to the isolation of three new sesquiterpene phenols, langconols A–C (1–3), and one new sesquiterpene hydroxyquinone, langcoquinone C (4), together with two known meroterpenoids (5 and 6). Their structures were determined on the basis of spectroscopic analyses and comparisons with published data. Furthermore, the antibacterial assays of the isolates 1–6 suggested that 4 and 6 had significant antibacterial activities against Bacillus subtilis and Staphylococcus aureus, with MICs ranging from 6.25 to 25.0 µM, while 1 and 3 possessed significant antibacterial activities against B. subtilis with MICs of 12.5 and 25.0 µM, respectively. In contrast, cytotoxic assays of the isolated compounds 1–6, as well as compounds 7–15 previously isolated from this sponge, indicated that 1 and the previously reported anti-B. subtilis and anti-S. aureus sesquiterpene phenol 9 lacked cytotoxic activities against three human cancer cell lines (A549, lung cancer; MCF7, breast cancer; HeLa, cervix cancer) and a human normal cell line (WI-38 fibroblast).

Original languageEnglish
Pages (from-to)3043-3047
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume27
Issue number14
DOIs
Publication statusPublished - 2017
Externally publishedYes

Keywords

  • Antibacterial activity
  • Cytotoxic activity
  • Meroterpenoids
  • Spongia sp.
  • Vietnam

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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