New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors

Takashi Yoshida; Hideyuki Ito; Tsutomu Hatano; Mari Kurata; Tsutomu Nakanishi; Akira Inada; Hiroko Murata; Yuka Inatomi; Nobuyasu Matsuura; Katsuhiko Ono; Hideo Nakane; Miho Noda; Frank A. Lang; Jin Murata

doi:10.1248/cpb.44.1436

New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors

Takashi Yoshida, Hideyuki Ito, Tsutomu Hatano, Mari Kurata, Tsutomu Nakanishi, Akira Inada, Hiroko Murata, Yuka Inatomi, Nobuyasu Matsuura, Katsuhiko Ono, Hideo Nakane, Miho Noda, Frank A. Lang, Jin Murata

Research output: Contribution to journal › Article

33 Citations (Scopus)

Abstract

Two new hydrolyzable tannins, shephagenins A and B, were isolated along with hippophaenin A and strictinin from the leaf extract of Shepherdia argentea, which showed a remarkable inhibitory activity against human immunodeficiency virus (HIV)-1 reverse transcriptase. Their structures, having a gluconic acid core, have been elucidated on the basis of spectroscopic and chemical methods. The inhibitory effect of the leaf extract on HIV-1 reverse transcriptase was found to be due to tannins, and their activities were stronger than that of (-)-epigallocatechin gallate as a positive control.

Original language	English
Pages (from-to)	1436-1439
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	44
Issue number	8
DOIs	https://doi.org/10.1248/cpb.44.1436
Publication status	Published - Aug 1996

Keywords

Elaeagnaceae
HIV-1 reverse transcriptase
Shepherdia argentea
shephagenin A
shephagenin B

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Access to Document

10.1248/cpb.44.1436

Fingerprint Dive into the research topics of 'New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors'. Together they form a unique fingerprint.

Cite this

Yoshida, T., Ito, H., Hatano, T., Kurata, M., Nakanishi, T., Inada, A., Murata, H., Inatomi, Y., Matsuura, N., Ono, K., Nakane, H., Noda, M., Lang, F. A., & Murata, J. (1996). New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors. Chemical and Pharmaceutical Bulletin, 44(8), 1436-1439. https://doi.org/10.1248/cpb.44.1436

New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors. / Yoshida, Takashi; Ito, Hideyuki; Hatano, Tsutomu; Kurata, Mari; Nakanishi, Tsutomu; Inada, Akira; Murata, Hiroko; Inatomi, Yuka; Matsuura, Nobuyasu; Ono, Katsuhiko; Nakane, Hideo; Noda, Miho; Lang, Frank A.; Murata, Jin.

In: Chemical and Pharmaceutical Bulletin, Vol. 44, No. 8, 08.1996, p. 1436-1439.

Research output: Contribution to journal › Article

Yoshida, T, Ito, H, Hatano, T, Kurata, M, Nakanishi, T, Inada, A, Murata, H, Inatomi, Y, Matsuura, N, Ono, K, Nakane, H, Noda, M, Lang, FA & Murata, J 1996, 'New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors', Chemical and Pharmaceutical Bulletin, vol. 44, no. 8, pp. 1436-1439. https://doi.org/10.1248/cpb.44.1436

Yoshida, Takashi ; Ito, Hideyuki ; Hatano, Tsutomu ; Kurata, Mari ; Nakanishi, Tsutomu ; Inada, Akira ; Murata, Hiroko ; Inatomi, Yuka ; Matsuura, Nobuyasu ; Ono, Katsuhiko ; Nakane, Hideo ; Noda, Miho ; Lang, Frank A. ; Murata, Jin. / New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors. In: Chemical and Pharmaceutical Bulletin. 1996 ; Vol. 44, No. 8. pp. 1436-1439.

@article{644fed46083e4bd288315756d4efe3d1,

title = "New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors",

abstract = "Two new hydrolyzable tannins, shephagenins A and B, were isolated along with hippophaenin A and strictinin from the leaf extract of Shepherdia argentea, which showed a remarkable inhibitory activity against human immunodeficiency virus (HIV)-1 reverse transcriptase. Their structures, having a gluconic acid core, have been elucidated on the basis of spectroscopic and chemical methods. The inhibitory effect of the leaf extract on HIV-1 reverse transcriptase was found to be due to tannins, and their activities were stronger than that of (-)-epigallocatechin gallate as a positive control.",

keywords = "Elaeagnaceae, HIV-1 reverse transcriptase, Shepherdia argentea, shephagenin A, shephagenin B",

author = "Takashi Yoshida and Hideyuki Ito and Tsutomu Hatano and Mari Kurata and Tsutomu Nakanishi and Akira Inada and Hiroko Murata and Yuka Inatomi and Nobuyasu Matsuura and Katsuhiko Ono and Hideo Nakane and Miho Noda and Lang, {Frank A.} and Jin Murata",

year = "1996",

month = aug,

doi = "10.1248/cpb.44.1436",

language = "English",

volume = "44",

pages = "1436--1439",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "8",

}

TY - JOUR

T1 - New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors

AU - Yoshida, Takashi

AU - Ito, Hideyuki

AU - Hatano, Tsutomu

AU - Kurata, Mari

AU - Nakanishi, Tsutomu

AU - Inada, Akira

AU - Murata, Hiroko

AU - Inatomi, Yuka

AU - Matsuura, Nobuyasu

AU - Ono, Katsuhiko

AU - Nakane, Hideo

AU - Noda, Miho

AU - Lang, Frank A.

AU - Murata, Jin

PY - 1996/8

Y1 - 1996/8

N2 - Two new hydrolyzable tannins, shephagenins A and B, were isolated along with hippophaenin A and strictinin from the leaf extract of Shepherdia argentea, which showed a remarkable inhibitory activity against human immunodeficiency virus (HIV)-1 reverse transcriptase. Their structures, having a gluconic acid core, have been elucidated on the basis of spectroscopic and chemical methods. The inhibitory effect of the leaf extract on HIV-1 reverse transcriptase was found to be due to tannins, and their activities were stronger than that of (-)-epigallocatechin gallate as a positive control.

AB - Two new hydrolyzable tannins, shephagenins A and B, were isolated along with hippophaenin A and strictinin from the leaf extract of Shepherdia argentea, which showed a remarkable inhibitory activity against human immunodeficiency virus (HIV)-1 reverse transcriptase. Their structures, having a gluconic acid core, have been elucidated on the basis of spectroscopic and chemical methods. The inhibitory effect of the leaf extract on HIV-1 reverse transcriptase was found to be due to tannins, and their activities were stronger than that of (-)-epigallocatechin gallate as a positive control.

KW - Elaeagnaceae

KW - HIV-1 reverse transcriptase

KW - Shepherdia argentea

KW - shephagenin A

KW - shephagenin B

UR - http://www.scopus.com/inward/record.url?scp=9544241425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9544241425&partnerID=8YFLogxK

U2 - 10.1248/cpb.44.1436

DO - 10.1248/cpb.44.1436

M3 - Article

C2 - 8795264

AN - SCOPUS:9544241425

VL - 44

SP - 1436

EP - 1439

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 8

ER -