Abstract
Two new hydrolyzable tannins, shephagenins A and B, were isolated along with hippophaenin A and strictinin from the leaf extract of Shepherdia argentea, which showed a remarkable inhibitory activity against human immunodeficiency virus (HIV)-1 reverse transcriptase. Their structures, having a gluconic acid core, have been elucidated on the basis of spectroscopic and chemical methods. The inhibitory effect of the leaf extract on HIV-1 reverse transcriptase was found to be due to tannins, and their activities were stronger than that of (-)-epigallocatechin gallate as a positive control.
| Original language | English |
|---|---|
| Pages (from-to) | 1436-1439 |
| Number of pages | 4 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 44 |
| Issue number | 8 |
| Publication status | Published - Aug 1 1996 |
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Keywords
- Elaeagnaceae
- HIV-1 reverse transcriptase
- Shepherdia argentea
- shephagenin A
- shephagenin B
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery
Cite this
Yoshida, T., Ito, H., Hatano, T., Kurata, M., Nakanishi, T., Inada, A., Murata, H., Inatomi, Y., Matsuura, N., Ono, K., Nakane, H., Noda, M., Lang, F. A., & Murata, J. (1996). New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors. Chemical and Pharmaceutical Bulletin, 44(8), 1436-1439.