Abstract
Two new hydrolyzable tannins, shephagenins A and B, were isolated along with hippophaenin A and strictinin from the leaf extract of Shepherdia argentea, which showed a remarkable inhibitory activity against human immunodeficiency virus (HIV)-1 reverse transcriptase. Their structures, having a gluconic acid core, have been elucidated on the basis of spectroscopic and chemical methods. The inhibitory effect of the leaf extract on HIV-1 reverse transcriptase was found to be due to tannins, and their activities were stronger than that of (-)-epigallocatechin gallate as a positive control.
Original language | English |
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Pages (from-to) | 1436-1439 |
Number of pages | 4 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 44 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 1996 |
Keywords
- Elaeagnaceae
- HIV-1 reverse transcriptase
- Shepherdia argentea
- shephagenin A
- shephagenin B
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery