New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors

Takashi Yoshida, Hideyuki Ito, Tsutomu Hatano, Mari Kurata, Tsutomu Nakanishi, Akira Inada, Hiroko Murata, Yuka Inatomi, Nobuyasu Matsuura, Katsuhiko Ono, Hideo Nakane, Miho Noda, Frank A. Lang, Jin Murata

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Abstract

Two new hydrolyzable tannins, shephagenins A and B, were isolated along with hippophaenin A and strictinin from the leaf extract of Shepherdia argentea, which showed a remarkable inhibitory activity against human immunodeficiency virus (HIV)-1 reverse transcriptase. Their structures, having a gluconic acid core, have been elucidated on the basis of spectroscopic and chemical methods. The inhibitory effect of the leaf extract on HIV-1 reverse transcriptase was found to be due to tannins, and their activities were stronger than that of (-)-epigallocatechin gallate as a positive control.

Original languageEnglish
Pages (from-to)1436-1439
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume44
Issue number8
Publication statusPublished - Aug 1 1996

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Keywords

  • Elaeagnaceae
  • HIV-1 reverse transcriptase
  • Shepherdia argentea
  • shephagenin A
  • shephagenin B

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

Cite this

Yoshida, T., Ito, H., Hatano, T., Kurata, M., Nakanishi, T., Inada, A., Murata, H., Inatomi, Y., Matsuura, N., Ono, K., Nakane, H., Noda, M., Lang, F. A., & Murata, J. (1996). New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors. Chemical and Pharmaceutical Bulletin, 44(8), 1436-1439.