New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors

Takashi Yoshida; Hideyuki Ito; Tsutomu Hatano; Mari Kurata; Tsutomu Nakanishi; Akira Inada; Hiroko Murata; Yuka Inatomi; Nobuyasu Matsuura; Katsuhiko Ono; Hideo Nakane; Miho Noda; Frank A. Lang; Jin Murata

doi:10.1248/cpb.44.1436

New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors

Takashi Yoshida, Hideyuki Ito, Tsutomu Hatano, Mari Kurata, Tsutomu Nakanishi, Akira Inada, Hiroko Murata, Yuka Inatomi, Nobuyasu Matsuura, Katsuhiko Ono, Hideo Nakane, Miho Noda, Frank A. Lang, Jin Murata

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Two new hydrolyzable tannins, shephagenins A and B, were isolated along with hippophaenin A and strictinin from the leaf extract of Shepherdia argentea, which showed a remarkable inhibitory activity against human immunodeficiency virus (HIV)-1 reverse transcriptase. Their structures, having a gluconic acid core, have been elucidated on the basis of spectroscopic and chemical methods. The inhibitory effect of the leaf extract on HIV-1 reverse transcriptase was found to be due to tannins, and their activities were stronger than that of (-)-epigallocatechin gallate as a positive control.

Original language	English
Pages (from-to)	1436-1439
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	44
Issue number	8
DOIs	https://doi.org/10.1248/cpb.44.1436
Publication status	Published - Aug 1996

Keywords

Elaeagnaceae
HIV-1 reverse transcriptase
Shepherdia argentea
shephagenin A
shephagenin B

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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Yoshida, T., Ito, H., Hatano, T., Kurata, M., Nakanishi, T., Inada, A., Murata, H., Inatomi, Y., Matsuura, N., Ono, K., Nakane, H., Noda, M., Lang, F. A., & Murata, J. (1996). New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors. Chemical and Pharmaceutical Bulletin, 44(8), 1436-1439. https://doi.org/10.1248/cpb.44.1436

New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors. / Yoshida, Takashi; Ito, Hideyuki; Hatano, Tsutomu; Kurata, Mari; Nakanishi, Tsutomu; Inada, Akira; Murata, Hiroko; Inatomi, Yuka; Matsuura, Nobuyasu; Ono, Katsuhiko; Nakane, Hideo; Noda, Miho; Lang, Frank A.; Murata, Jin.

In: Chemical and Pharmaceutical Bulletin, Vol. 44, No. 8, 08.1996, p. 1436-1439.

Research output: Contribution to journal › Article › peer-review

Yoshida, T, Ito, H, Hatano, T, Kurata, M, Nakanishi, T, Inada, A, Murata, H, Inatomi, Y, Matsuura, N, Ono, K, Nakane, H, Noda, M, Lang, FA & Murata, J 1996, 'New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors', Chemical and Pharmaceutical Bulletin, vol. 44, no. 8, pp. 1436-1439. https://doi.org/10.1248/cpb.44.1436

Yoshida, Takashi ; Ito, Hideyuki ; Hatano, Tsutomu ; Kurata, Mari ; Nakanishi, Tsutomu ; Inada, Akira ; Murata, Hiroko ; Inatomi, Yuka ; Matsuura, Nobuyasu ; Ono, Katsuhiko ; Nakane, Hideo ; Noda, Miho ; Lang, Frank A. ; Murata, Jin. / New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors. In: Chemical and Pharmaceutical Bulletin. 1996 ; Vol. 44, No. 8. pp. 1436-1439.

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