New functional aspects of CCN2 revealed by trans-omic approaches

Background CCN family protein 2 (CCN2), also widely known as connective tissue growth factor (CTGF), is one of the classical members of the CCN family of proteins. In mammals, the CCN family comprises 6 members, each of which is composed of highly interactive conserved modules. Therefore, the biological roles of CCN2 in different microenvironments are highly diverse and depend on the cofactors present. Highlight In cartilage, CCN2 promotes chondrocyte proliferation and differentiation, which was evidenced by its ability to regenerate damaged articular cartilage in a harmonized manner. However, the mechanism by which CCN2 promotes both proliferation and differentiation - apparently opposite cytological events - remains unclear. In order to clarify the mechanism underlying the diverse functionality of CCN2, novel approaches are needed. Recent advances in omics approaches that attempt to address these issues are introduced in this review. Conclusion A new functional aspect of CCN2 as a metabolic supporter in cartilage was recently revealed by a metabolo-transcriptomic approach. In addition, a systematic interactomic approach is being used to characterize the molecular network around CCN2 that supports the multiple functionality of CCN2 in bone/cartilage.