New cytotoxic phenolic derivatives from matured fruits of magnolia denudata

Toshiro Noshita; Hiromasa Kiyota; Yumi Kidachi; Kazuo Ryoyama; Shinji Funayama; Ken Hanada; Tetsuya Murayama

doi:10.1271/bbb.80597

New cytotoxic phenolic derivatives from matured fruits of magnolia denudata

Toshiro Noshita, Hiromasa Kiyota, Yumi Kidachi, Kazuo Ryoyama, Shinji Funayama, Ken Hanada, Tetsuya Murayama

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Magnolia species are widely cultivated in Japan as garden plants, and have been found to contain various compounds, including alkaloids, terpenoids, lignans, and neolignans. The constituents of the mature fruits of M. denudata were investigated, and two new phenolic derivatives, named denudalide and denudaquinol, were isolated and characterized, together with a known neolignan compound (denudatin A). Denudalide and denudaquinol showed cytotoxicity against the SFME and r/mHM-SFME-1 cell lines.

Original language	English
Pages (from-to)	726-728
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	73
Issue number	3
DOIs	https://doi.org/10.1271/bbb.80597
Publication status	Published - 2009
Externally published	Yes

Keywords

Benzofuranone
Cytotoxic metabolite
Denudalide
Denudaquinol
Magnolia denudata

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.80597

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title = "New cytotoxic phenolic derivatives from matured fruits of magnolia denudata",

abstract = "Magnolia species are widely cultivated in Japan as garden plants, and have been found to contain various compounds, including alkaloids, terpenoids, lignans, and neolignans. The constituents of the mature fruits of M. denudata were investigated, and two new phenolic derivatives, named denudalide and denudaquinol, were isolated and characterized, together with a known neolignan compound (denudatin A). Denudalide and denudaquinol showed cytotoxicity against the SFME and r/mHM-SFME-1 cell lines.",

keywords = "Benzofuranone, Cytotoxic metabolite, Denudalide, Denudaquinol, Magnolia denudata",

author = "Toshiro Noshita and Hiromasa Kiyota and Yumi Kidachi and Kazuo Ryoyama and Shinji Funayama and Ken Hanada and Tetsuya Murayama",

year = "2009",

doi = "10.1271/bbb.80597",

language = "English",

volume = "73",

pages = "726--728",

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T1 - New cytotoxic phenolic derivatives from matured fruits of magnolia denudata

AU - Noshita, Toshiro

AU - Kiyota, Hiromasa

AU - Kidachi, Yumi

AU - Ryoyama, Kazuo

AU - Funayama, Shinji

AU - Hanada, Ken

AU - Murayama, Tetsuya

PY - 2009

Y1 - 2009

N2 - Magnolia species are widely cultivated in Japan as garden plants, and have been found to contain various compounds, including alkaloids, terpenoids, lignans, and neolignans. The constituents of the mature fruits of M. denudata were investigated, and two new phenolic derivatives, named denudalide and denudaquinol, were isolated and characterized, together with a known neolignan compound (denudatin A). Denudalide and denudaquinol showed cytotoxicity against the SFME and r/mHM-SFME-1 cell lines.

AB - Magnolia species are widely cultivated in Japan as garden plants, and have been found to contain various compounds, including alkaloids, terpenoids, lignans, and neolignans. The constituents of the mature fruits of M. denudata were investigated, and two new phenolic derivatives, named denudalide and denudaquinol, were isolated and characterized, together with a known neolignan compound (denudatin A). Denudalide and denudaquinol showed cytotoxicity against the SFME and r/mHM-SFME-1 cell lines.

KW - Benzofuranone

KW - Cytotoxic metabolite

KW - Denudalide

KW - Denudaquinol

KW - Magnolia denudata

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JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

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New cytotoxic phenolic derivatives from matured fruits of magnolia denudata

Abstract

Keywords

ASJC Scopus subject areas

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