New cytotoxic phenolic derivatives from matured fruits of magnolia denudata

Toshiro Noshita, Hiromasa Kiyota, Yumi Kidachi, Kazuo Ryoyama, Shinji Funayama, Ken Hanada, Tetsuya Murayama

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Magnolia species are widely cultivated in Japan as garden plants, and have been found to contain various compounds, including alkaloids, terpenoids, lignans, and neolignans. The constituents of the mature fruits of M. denudata were investigated, and two new phenolic derivatives, named denudalide and denudaquinol, were isolated and characterized, together with a known neolignan compound (denudatin A). Denudalide and denudaquinol showed cytotoxicity against the SFME and r/mHM-SFME-1 cell lines.

Original languageEnglish
Pages (from-to)726-728
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Issue number3
Publication statusPublished - 2009
Externally publishedYes


  • Benzofuranone
  • Cytotoxic metabolite
  • Denudalide
  • Denudaquinol
  • Magnolia denudata

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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