New aspects of neuroprotective effects of nonsteroidal anti-inflammatory drugs

Masato Asanuma, Ikuko Miyazaki, Takeshi Tsuji, Norio Ogawa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) exert anti -inflammatory, analgesic and antipyretic activities and are involved in the suppression of prostaglandin synthesis by inhibiting cyclooxygenase (COX), a prostaglandin synthesizing enzyme. It has been recently revealed that NSAIDs also possess inhibitory effects on the generating system of nitric oxide radicals and modulating effects on transcription factors and nuclear receptors which are related to inflammatory reactions. Since it has been reported that inflammatory processes are associated with the pathophysiology of several neurodegenerative diseases and that NSAIDs inhibit amyloid β-protein-induced neurotoxicity to reduce the risk for Alzheimer's disease, a number of studies have been conducted focusing on the neuroprotective effects of NSAIDs. It has been clarified that the drugs exert neuroprotective effects, which are not related to their COX-inhibiting property, on pathophysiology of various neurological disorders. In this article, new aspects of neuroprotective effects of NSAIDs have been reviewed, especially, in Alzheimer's disease and Parkinson's disease, discussing various pharmacological effects of NSAIDs other than their inhibitory action on COX.

Original languageEnglish
Pages (from-to)111-119
Number of pages9
JournalJapanese Journal of Neuropsychopharmacology
Volume23
Issue number3
Publication statusPublished - Jun 2003

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Keywords

  • Alzheimer's disease
  • Inflammation
  • Neuroprotection
  • Nonsteroidal anti-inflammatory drugs
  • Parkinson's disease

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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