New analogs of pochonicine, a potent β-N-acetylglucosaminidase inhibitor from fungus Pochonia suchlasporia var. suchlasporia TAMA 87

Yuhichi Mushiake, Aya Tsuchida, Asami Yamada, Hiroshi Kanzaki, Toru Okuda, Teruhiko Nitoda

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Three novel analogs of pochonicine (1) were isolated from a solid fermentation culture of the fungal strain Pochonia suchlasporia var. suchlasporia TAMA 87, and their structures were elucidated as 7-deoxypochonicine (2), 6-deoxypochonicine (3), and 6,7-dideoxypochonicine (4). These analogs were found to possess the same stereochemistry as pochonicine. Comparison of β-N-acetylglucosaminidase (GlcNAcase) inhibitory activity between these analogs and pochonicine suggested that the C-6 hydroxy group of pochonicine was essential to its potent GlcNAcase inhibitory activity and that the C-7 hydroxy group also contributed to the activity, but to a lesser extent than the C-6 hydroxy group.

Original languageEnglish
Pages (from-to)115-119
Number of pages5
JournalJournal of Pesticide Science
Volume46
Issue number1
DOIs
Publication statusPublished - 2021

Keywords

  • Pochonia suchlasporia
  • chitinolytic enzyme
  • pochonicine
  • solid state fermentation
  • β-N-acetylglucosaminidase inhibitor

ASJC Scopus subject areas

  • Insect Science
  • Health, Toxicology and Mutagenesis

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