Neutrophils as a source of cytokines in inflammation

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

The recruitment of neutrophils into inflammatory foci is a fundamental process observed in inflammation. The function of neutrophils has long been regarded only as an effector cell that kills the invading pathogens. Recent evidence has demonstrated that neutrophils are capable of producing inflammatory cytokines. The findings are, however, mainly based on the findings obtained in vitro. It has not been fully elucidated if neutrophils could synthesize and secrete cytokines in vivo. Animal models of inflammation are essential to address the issue and provide insight into the involvement of neutrophils in producing cytokines.

Original languageEnglish
Pages (from-to)511-516
Number of pages6
JournalHistology and Histopathology
Volume14
Issue number2
Publication statusPublished - Jan 1 1999
Externally publishedYes

Keywords

  • Acute inflammation
  • Cytokine
  • Neutrophil

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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