Neutrophil and lymphocyte responses to oral Streptococcus in Adamantiades-Behçet's disease

Tomomi Kurauchi, Kenji Yokota, Toshihiko Matsuo, Yoshihito Fujinami, Emiko Isogai, Hiroshi Isogai, Hiroshi Ohtsuki, Keiji Oguma

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Immune reactions against microorganisms play an important pathogenic role in Adamantiades-Behçet's disease. We had previously obtained Streptococcus sanguinis (strain BD113-20), isolated from the oral cavity of patients with Adamantiades-Behçet's syndrome. To investigate the pathogenesis of this isolate, we examined neutrophil reactions and levels of cytokine production by lymphocytes after stimulation with the strain. The reactions of neutrophils were examined by chemiluminescence assay using whole blood. The amounts of interferon gamma (IFN-γ) and interleukin (IL)-4, IL-8, IL-10 and IL-12, produced by peripheral blood mononuclear cells, were measured by ELISA. Strain BD113-20 activated neutrophils from Adamantiades-Behçet's patients and healthy volunteers, and, in addition it increased the IFN-γ production by lymphocytes. Lymphocytes from Adamantiades-Behçet's patients showed a dominant T helper-1 immune response. Results indicated that both bacterial stimulation and host hypersensitivity might be involved in the symptoms and pathogenesis of Adamantiades-Behçet's disease.

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalFEMS Immunology and Medical Microbiology
Volume43
Issue number2
DOIs
Publication statusPublished - Feb 1 2005

Fingerprint

Streptococcus
Neutrophils
Lymphocytes
Interferon-gamma
Interleukin-12
Lymphocyte Activation
Luminescence
Interleukin-8
Interleukin-4
Interleukin-10
Mouth
Blood Cells
Healthy Volunteers
Hypersensitivity
Enzyme-Linked Immunosorbent Assay
Cytokines

Keywords

  • Adamantiades-Behcet's disease
  • Chemiluminescence
  • IFN-γ
  • IL-12
  • IL-8
  • Neutrophil
  • Streptococcus sanguinis
  • T helper-1

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Infectious Diseases

Cite this

Neutrophil and lymphocyte responses to oral Streptococcus in Adamantiades-Behçet's disease. / Kurauchi, Tomomi; Yokota, Kenji; Matsuo, Toshihiko; Fujinami, Yoshihito; Isogai, Emiko; Isogai, Hiroshi; Ohtsuki, Hiroshi; Oguma, Keiji.

In: FEMS Immunology and Medical Microbiology, Vol. 43, No. 2, 01.02.2005, p. 125-131.

Research output: Contribution to journalArticle

Kurauchi, Tomomi ; Yokota, Kenji ; Matsuo, Toshihiko ; Fujinami, Yoshihito ; Isogai, Emiko ; Isogai, Hiroshi ; Ohtsuki, Hiroshi ; Oguma, Keiji. / Neutrophil and lymphocyte responses to oral Streptococcus in Adamantiades-Behçet's disease. In: FEMS Immunology and Medical Microbiology. 2005 ; Vol. 43, No. 2. pp. 125-131.
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