Neurovirulent strains of herpes simplex virus type 1 are not necessarily competent for reactivatable latency.

Y. Arao, A. Hatano, M. Yamada, F. Uno, S. Nii

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Ability of two neurovirulent strains (F and +GC (LPV) Miyama) of herpes simplex virus type 1 (HSV-1) to establish and maintain reactivatable latency in trigeminal ganglia (TG) was compared after intranasal inoculation of mice. The +GC (LPV) Miyama strain showed a very low rate of virus reactivation in explant cultures of TG, while the F strain showed a high rate of reactivation. These data indicate that neurovirulent strains of HSV-1 are not always competent for reactivatable latency, although most virulent strains of HSV-1 thus far reported were competent for reactivatable latency.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalActa medica Okayama
Issue number2
Publication statusPublished - Apr 1991


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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