Neurosyphilis is a long-forgotten disease but still a possible etiology for dementia

Hideharu Hagiya, Kentaro Deguchi, Kiyohiro Kawada, Fumio Otsuka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We herein report a heterosexual Japanese man in his forties who had been suffering from advanced dementia and personality change for 4 years. Positive results of a serological test for syphilis, Treponema pallidum hemagglutination assay, and fluorescent treponemal antibody-absorption test of both serum and cerebral spinal fluid led to the diagnosis of neurosyphilis. Jarisch-Herxheimer reaction was seen shortly after the first dose of penicillin was administered to the patient. His cognitive function did not recover after treatment. The incidence of syphilis has been reported to be increasing. Neurosyphilis should not be overlooked as an etiology for progressive dementia even in this post-antibiotic era.

Original languageEnglish
Pages (from-to)2769-2773
Number of pages5
JournalInternal Medicine
Volume54
Issue number21
DOIs
Publication statusPublished - Nov 1 2015

Fingerprint

Neurosyphilis
Syphilis
Dementia
Fluorescent Treponemal Antibody-Absorption Test
Treponema pallidum
Heterosexuality
Hemagglutination
Serologic Tests
Penicillins
Cognition
Personality
Anti-Bacterial Agents
Incidence
Serum
Therapeutics

Keywords

  • Dementia
  • Jarisch-Herxheimer reaction (JHR)
  • Spirochete
  • Syphilis
  • Treponema pallidum

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Neurosyphilis is a long-forgotten disease but still a possible etiology for dementia. / Hagiya, Hideharu; Deguchi, Kentaro; Kawada, Kiyohiro; Otsuka, Fumio.

In: Internal Medicine, Vol. 54, No. 21, 01.11.2015, p. 2769-2773.

Research output: Contribution to journalArticle

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