Neuroprotective Effects of Tocovid Pretreatment in a Mouse Stroke Model

Yang Jiao, Jingwei Shang, Yasuyuki Ohta, Hongjing Yan, Xia Liu, Xianghong Li, Ryuta Morihara, Yumiko Nakano, Yusuke Fukui, Xiaowen Shi, Yong Huang, Tian Feng, Mami Takemoto, Kota Sato, Nozomi Hishikawa, Toru Yamashita, Koji Abe

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Tocovid is a new combination of tocotrienols and tocopherol, both of which are neuroprotective agents for preventing cerebral infarction in mice. However, the effects of tocovid on anti-inflammation in ischemic model remain elusive. In the present study, we assessed the effects of Tocovid pretreatment on anti-inflammatory effects after transient middle cerebral occlusion (tMCAO) in mice. Materials and Methods: We evaluated the therapeutic and anti-inflammatory effects of tocovid pretreatment (200 mg/kg per day, for 1 month) on mice brain under 60 minutes of tMCAO. The expressive changes of inflammatory markers were observed after tMCAO in mice. Results: Tocovid pretreatment greatly improved the mice neurobehaviors, reduced infarct volumes and decreased expressions of inflammatory markers such as tumor necrosis factor-α (TNF-α), monocyte chemotactic protein-1 (MCP-1) and ionized calcium binding adapter molecule-1 (Iba-1), and improved the damage of neurovascular units including matrix metallopeptidase 9, IgG and collagen IV after tMCAO. Conclusions: Our present findings demonstrated that oral tocovid pretreatment showed obviously neuroprotective and at least in part by anti-inflammatory effects in ischemic mice brain.

Original languageEnglish
Pages (from-to)2166-2174
Number of pages9
JournalJournal of Stroke and Cerebrovascular Diseases
Volume27
Issue number8
DOIs
Publication statusPublished - Aug 2018

Keywords

  • Neuroinflammation
  • neurovascular unit dissociation
  • tocovid
  • transient middle cerebral occlusion

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Jiao, Y., Shang, J., Ohta, Y., Yan, H., Liu, X., Li, X., Morihara, R., Nakano, Y., Fukui, Y., Shi, X., Huang, Y., Feng, T., Takemoto, M., Sato, K., Hishikawa, N., Yamashita, T., & Abe, K. (2018). Neuroprotective Effects of Tocovid Pretreatment in a Mouse Stroke Model. Journal of Stroke and Cerebrovascular Diseases, 27(8), 2166-2174. https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.03.014