Neuroprotective effects of nonsteroidal anti-inflammatory drugs on neurodegenerative diseases

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

It is well known that nonsteroidal anti-inflammatory drugs (NSAIDs) possess anti-inflammatory, analgesic and antipyretic properties by inhibiting cyclooxygenase (COX), a prostaglandin-synthesizing enzyme. It has also been revealed that NSAIDs exert inhibitory effects on the generating system of nitric oxide radicals and modulating effects on transcription factors which are related to inflammatory reactions including cytokine expression. Recently, a number of studies have been conducted focusing on the neuroprotective effects of NSAIDs, since it has been reported that inflammatory processes are associated with the pathogenesis of several neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. In the experimental model of Parkinson's disease, NSAIDs have also exerted neuroprotective effects which are based not only on their COX-inhibiting effects but also on other properties: inhibitory effects on nitric oxide synthesis, action as agonists for peroxisome proliferator-activated receptor γ, and some unknown pharmacological effects. In this article, various pharmacological effects of NSAIDs except their inhibitory action on COX are reviewed, and possible neuroprotective effects of NSAIDs have been discussed on neurodegenerative diseases, especially Parkinson's disease.

Original languageEnglish
Pages (from-to)695-700
Number of pages6
JournalCurrent Pharmaceutical Design
Volume10
Issue number6
DOIs
Publication statusPublished - 2004

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Neuroprotective Agents
Neurodegenerative Diseases
Anti-Inflammatory Agents
Prostaglandin-Endoperoxide Synthases
Pharmaceutical Preparations
Parkinson Disease
Nitric Oxide
Pharmacology
Antipyretics
Peroxisome Proliferator-Activated Receptors
Parkinsonian Disorders
Non-Steroidal Anti-Inflammatory Agents
Alzheimer Disease
Transcription Factors
Theoretical Models
Cytokines
Enzymes

Keywords

  • Cyclooxygenase
  • Gliosis
  • Inflammation
  • Neuroprotection
  • Nitric oxide
  • Nonsteroidal anti-inflammatory drugs
  • Parkinson's disease
  • Peroxisome proliferator-activated receptor γ

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Neuroprotective effects of nonsteroidal anti-inflammatory drugs on neurodegenerative diseases. / Asanuma, Masato; Miyazaki, Ikuko; Ogawa, N.

In: Current Pharmaceutical Design, Vol. 10, No. 6, 2004, p. 695-700.

Research output: Contribution to journalArticle

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