Neuroprotective effect of CuATSM in mice stroke model by ameliorating oxidative stress

Xiaowen Shi, Yasuyuki Ohta, Yumiko Nakano, Xia Liu, Koh Tadokoro, Tian Feng, Emi Nomura, Keiichiro Tsunoda, Ryo Sasaki, Namiko Matsumoto, Yosuke Osakada, Yuting Bian, Zhihong Bian, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Koji Abe

Research output: Contribution to journalArticle

Abstract

Cu-diacetyl-bis (N4-methylthiosemicarbazone) (CuATSM) has both anti-oxidative and anti-inflammatory activities, but its therapeutic efficacy for oxidative stress has not been thoroughly investigated in acute ischemic stroke. Here, the present study was designed to assess the efficacies of CuATSM in acute ischemic stroke by comparing with the standard neuroprotective reagent edaravone. Mice were subjected to transient middle cerebral occlusion (tMCAO) for 60 min, and then intravenously administrated with CuATSM (1.5 mg/kg) or edaravone (3 mg/kg) just after the reperfusion, and examined at 1 and 3 d. Compared with the vehicle group, CuATSM treatment decreased infarct volumes and oxidative stress at 3d after tMCAO, which was further enhanced by combined CuATSM + edaravone treatment as compared with single CuATSM group, but not improve neurobehaviors. The present study demonstrated that CuATSM showed strong antioxidative and neuroprotective effects in acute ischemic stroke, which was enhanced by the combination with edaravone.

Original languageEnglish
JournalNeuroscience Research
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • CuATSM
  • Edaravone
  • Oxidative stress
  • Stroke
  • Transient middle cerebral artery occlusion

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Shi, X., Ohta, Y., Nakano, Y., Liu, X., Tadokoro, K., Feng, T., Nomura, E., Tsunoda, K., Sasaki, R., Matsumoto, N., Osakada, Y., Bian, Y., Bian, Z., Omote, Y., Takemoto, M., Hishikawa, N., Yamashita, T., & Abe, K. (Accepted/In press). Neuroprotective effect of CuATSM in mice stroke model by ameliorating oxidative stress. Neuroscience Research. https://doi.org/10.1016/j.neures.2020.05.009